Accessibility of circulation immunoglobulin G to the extravascular compartment of solid rat tumors

The authors have measured the rate of influx (K sub(in)) of normal rat immunoglobulin G (IgG) from the blood into the fluid surrounding the cells of three syngeneic rat fibrosarcomas as well as rat skin, muscle, lung, and kidney. Also measured was the rate of efflux (k sub(out)) of IgG from the tumo...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1984-01, Vol.44 (9), p.3719-3724
Main Authors: O'Connor, S W, Bale, W F
Format: Article
Language:English
Online Access:Get full text
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Summary:The authors have measured the rate of influx (K sub(in)) of normal rat immunoglobulin G (IgG) from the blood into the fluid surrounding the cells of three syngeneic rat fibrosarcomas as well as rat skin, muscle, lung, and kidney. Also measured was the rate of efflux (k sub(out)) of IgG from the tumor and tissue back into the circulation. Dividing k sub(in) by the plasma volume of the tissue gave a measure of the permeability of the vacular bed of that tissue. This ratio was rather constant for the normal tissues studied; however, it was at least an order of magnitude larger in all three tumors, indicating that the vasculature of the tumors was very permeable to IgG. A model for Ab localization onto solid tumors was developed. The model was used to discuss the mechanism of localization as well as the physiological limits of drug- or isotope-coupled Ab localization.
ISSN:0008-5472