The mechanism of inhibition by H2 of H2-evolution by hydrogenases

By analysing the results of experiments carried out with two FeFe hydrogenases and several "channel mutants" of a NiFe hydrogenase, we demonstrate that whether or not hydrogen evolution is significantly inhibited by H2 is not a consequence of active site chemistry, but rather relates to H2...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (61), p.6840-6842
Main Authors: Fourmond, Vincent, Baffert, Carole, Sybirna, Kateryna, Dementin, Sébastien, Abou-Hamdan, Abbas, Meynial-Salles, Isabelle, Soucaille, Philippe, Bottin, Hervé, Léger, Christophe
Format: Article
Language:English
Subjects:
Hydrogen - chemistry
Hydrogen - metabolism
Hydrogenase - metabolism
Iron-Sulfur Proteins - metabolism
Models, Molecular
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Summary:By analysing the results of experiments carried out with two FeFe hydrogenases and several "channel mutants" of a NiFe hydrogenase, we demonstrate that whether or not hydrogen evolution is significantly inhibited by H2 is not a consequence of active site chemistry, but rather relates to H2 transport within the enzyme.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc43297a