Nine Kindreds of Familial Sticky Platelet Syndrome Phenotype

Introduction: Sticky platelet syndrome (SPS) is most likely a hereditary thrombophilia characterized by platelet hyperaggregation after low concentrations of platelet inducers—adenosine diphosphate and/or epinephrine. We present 9 kindreds with SPS familial occurrence. Material and Methods: Familial...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis 2013-07, Vol.19 (4), p.395-401
Main Authors: Šimonová, Radoslava, Bartošová, Lenka, Chudý, Peter, Staško, Ján, Rumanová, Stanislava, Sokol, Juraj, Kubisz, Peter
Format: Article
Language:English
Subjects:
Adolescent
Adult
Blood Platelet Disorders - genetics
Child, Preschool
Family Health
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Pedigree
Phenotype
Syndrome
Thrombophilia - genetics
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction: Sticky platelet syndrome (SPS) is most likely a hereditary thrombophilia characterized by platelet hyperaggregation after low concentrations of platelet inducers—adenosine diphosphate and/or epinephrine. We present 9 kindreds with SPS familial occurrence. Material and Methods: Familial trait of SPS was looked up in the database of the National Center of Hemostasis and Thrombosis. Families with at least 3 SPS-positive members were studied, described, and presented. Results: In the group of 1093 symptomatic patients, SPS was confirmed in 240 cases. Familial occurrence with at least 3 SPS-positive relatives was found in 9 cases. Conclusion: The exact pathogenesis of SPS is not sufficiently explained. Our findings seem to support the idea that SPS might have an autosomal dominant hereditary fashion.
ISSN:1076-0296
1938-2723
DOI:10.1177/1076029612439340