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Nine Kindreds of Familial Sticky Platelet Syndrome Phenotype
Introduction: Sticky platelet syndrome (SPS) is most likely a hereditary thrombophilia characterized by platelet hyperaggregation after low concentrations of platelet inducers—adenosine diphosphate and/or epinephrine. We present 9 kindreds with SPS familial occurrence. Material and Methods: Familial...
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| Published in: | Clinical and applied thrombosis/hemostasis 2013-07, Vol.19 (4), p.395-401 |
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| container_end_page | 401 |
| container_issue | 4 |
| container_start_page | 395 |
| container_title | Clinical and applied thrombosis/hemostasis |
| container_volume | 19 |
| creator | Šimonová, Radoslava Bartošová, Lenka Chudý, Peter Staško, Ján Rumanová, Stanislava Sokol, Juraj Kubisz, Peter |
| description | Introduction:
Sticky platelet syndrome (SPS) is most likely a hereditary thrombophilia characterized by platelet hyperaggregation after low concentrations of platelet inducers—adenosine diphosphate and/or epinephrine. We present 9 kindreds with SPS familial occurrence.
Material and Methods:
Familial trait of SPS was looked up in the database of the National Center of Hemostasis and Thrombosis. Families with at least 3 SPS-positive members were studied, described, and presented.
Results:
In the group of 1093 symptomatic patients, SPS was confirmed in 240 cases. Familial occurrence with at least 3 SPS-positive relatives was found in 9 cases.
Conclusion:
The exact pathogenesis of SPS is not sufficiently explained. Our findings seem to support the idea that SPS might have an autosomal dominant hereditary fashion. |
| doi_str_mv | 10.1177/1076029612439340 |
| format | article |
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Sticky platelet syndrome (SPS) is most likely a hereditary thrombophilia characterized by platelet hyperaggregation after low concentrations of platelet inducers—adenosine diphosphate and/or epinephrine. We present 9 kindreds with SPS familial occurrence.
Material and Methods:
Familial trait of SPS was looked up in the database of the National Center of Hemostasis and Thrombosis. Families with at least 3 SPS-positive members were studied, described, and presented.
Results:
In the group of 1093 symptomatic patients, SPS was confirmed in 240 cases. Familial occurrence with at least 3 SPS-positive relatives was found in 9 cases.
Conclusion:
The exact pathogenesis of SPS is not sufficiently explained. Our findings seem to support the idea that SPS might have an autosomal dominant hereditary fashion.</description><identifier>ISSN: 1076-0296</identifier><identifier>EISSN: 1938-2723</identifier><identifier>DOI: 10.1177/1076029612439340</identifier><identifier>PMID: 22431856</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Adult ; Blood Platelet Disorders - genetics ; Child, Preschool ; Family Health ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Pedigree ; Phenotype ; Syndrome ; Thrombophilia - genetics ; Young Adult</subject><ispartof>Clinical and applied thrombosis/hemostasis, 2013-07, Vol.19 (4), p.395-401</ispartof><rights>The Author(s) 2012</rights><rights>The Author(s) 2012. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-2a3b85182d7122e2310a43a03dcf5b6d45eba80beaa2f1c82877974c05985b963</citedby><cites>FETCH-LOGICAL-c365t-2a3b85182d7122e2310a43a03dcf5b6d45eba80beaa2f1c82877974c05985b963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1076029612439340$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2344187317?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,21946,25732,27832,27903,27904,36991,36992,44569,44924,45312</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1076029612439340?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22431856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Šimonová, Radoslava</creatorcontrib><creatorcontrib>Bartošová, Lenka</creatorcontrib><creatorcontrib>Chudý, Peter</creatorcontrib><creatorcontrib>Staško, Ján</creatorcontrib><creatorcontrib>Rumanová, Stanislava</creatorcontrib><creatorcontrib>Sokol, Juraj</creatorcontrib><creatorcontrib>Kubisz, Peter</creatorcontrib><title>Nine Kindreds of Familial Sticky Platelet Syndrome Phenotype</title><title>Clinical and applied thrombosis/hemostasis</title><addtitle>Clin Appl Thromb Hemost</addtitle><description>Introduction:
Sticky platelet syndrome (SPS) is most likely a hereditary thrombophilia characterized by platelet hyperaggregation after low concentrations of platelet inducers—adenosine diphosphate and/or epinephrine. We present 9 kindreds with SPS familial occurrence.
Material and Methods:
Familial trait of SPS was looked up in the database of the National Center of Hemostasis and Thrombosis. Families with at least 3 SPS-positive members were studied, described, and presented.
Results:
In the group of 1093 symptomatic patients, SPS was confirmed in 240 cases. Familial occurrence with at least 3 SPS-positive relatives was found in 9 cases.
Conclusion:
The exact pathogenesis of SPS is not sufficiently explained. Our findings seem to support the idea that SPS might have an autosomal dominant hereditary fashion.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Blood Platelet Disorders - genetics</subject><subject>Child, Preschool</subject><subject>Family Health</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pedigree</subject><subject>Phenotype</subject><subject>Syndrome</subject><subject>Thrombophilia - genetics</subject><subject>Young Adult</subject><issn>1076-0296</issn><issn>1938-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp1kM1Lw0AQxRdRrFbvniTgxUt0Zzf7BV6kWBWLFqrnsEkmmpqPmk0O-e_d0qpQ8DQD7_feDI-QM6BXAEpdA1WSMiOBRdzwiO6RIzBch0wxvu93L4drfUSOnVtSCkYaeUhGzPOghTwiN89FjcFTUWctZi5o8mBqq6IsbBksuiL9HIJ5aTsssQsWg4eaCoP5B9ZNN6zwhBzktnR4up1j8ja9e508hLOX-8fJ7SxMuRRdyCxPtADNMgWMIeNAbcQt5Vmai0RmkcDEapqgtSyHVDOtlFFRSoXRIjGSj8nlJnfVNl89ui6uCpdiWdoam97FwI2OuKCgPXqxgy6bvq39dzHjUQRacVCeohsqbRvnWszjVVtUth1ioPG62Xi3WW853wb3SYXZr-GnSg-EG8DZd_y7-m_gN0dxfXQ</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Šimonová, Radoslava</creator><creator>Bartošová, Lenka</creator><creator>Chudý, Peter</creator><creator>Staško, Ján</creator><creator>Rumanová, Stanislava</creator><creator>Sokol, Juraj</creator><creator>Kubisz, Peter</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201307</creationdate><title>Nine Kindreds of Familial Sticky Platelet Syndrome Phenotype</title><author>Šimonová, Radoslava ; Bartošová, Lenka ; Chudý, Peter ; Staško, Ján ; Rumanová, Stanislava ; Sokol, Juraj ; Kubisz, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-2a3b85182d7122e2310a43a03dcf5b6d45eba80beaa2f1c82877974c05985b963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Blood Platelet Disorders - genetics</topic><topic>Child, Preschool</topic><topic>Family Health</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pedigree</topic><topic>Phenotype</topic><topic>Syndrome</topic><topic>Thrombophilia - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Šimonová, Radoslava</creatorcontrib><creatorcontrib>Bartošová, Lenka</creatorcontrib><creatorcontrib>Chudý, Peter</creatorcontrib><creatorcontrib>Staško, Ján</creatorcontrib><creatorcontrib>Rumanová, Stanislava</creatorcontrib><creatorcontrib>Sokol, Juraj</creatorcontrib><creatorcontrib>Kubisz, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and applied thrombosis/hemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Šimonová, Radoslava</au><au>Bartošová, Lenka</au><au>Chudý, Peter</au><au>Staško, Ján</au><au>Rumanová, Stanislava</au><au>Sokol, Juraj</au><au>Kubisz, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nine Kindreds of Familial Sticky Platelet Syndrome Phenotype</atitle><jtitle>Clinical and applied thrombosis/hemostasis</jtitle><addtitle>Clin Appl Thromb Hemost</addtitle><date>2013-07</date><risdate>2013</risdate><volume>19</volume><issue>4</issue><spage>395</spage><epage>401</epage><pages>395-401</pages><issn>1076-0296</issn><eissn>1938-2723</eissn><abstract>Introduction:
Sticky platelet syndrome (SPS) is most likely a hereditary thrombophilia characterized by platelet hyperaggregation after low concentrations of platelet inducers—adenosine diphosphate and/or epinephrine. We present 9 kindreds with SPS familial occurrence.
Material and Methods:
Familial trait of SPS was looked up in the database of the National Center of Hemostasis and Thrombosis. Families with at least 3 SPS-positive members were studied, described, and presented.
Results:
In the group of 1093 symptomatic patients, SPS was confirmed in 240 cases. Familial occurrence with at least 3 SPS-positive relatives was found in 9 cases.
Conclusion:
The exact pathogenesis of SPS is not sufficiently explained. Our findings seem to support the idea that SPS might have an autosomal dominant hereditary fashion.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>22431856</pmid><doi>10.1177/1076029612439340</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical and applied thrombosis/hemostasis, 2013-07, Vol.19 (4), p.395-401 |
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| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Adolescent Adult Blood Platelet Disorders - genetics Child, Preschool Family Health Female Gene Frequency Genetic Predisposition to Disease Humans Male Middle Aged Pedigree Phenotype Syndrome Thrombophilia - genetics Young Adult |
| title | Nine Kindreds of Familial Sticky Platelet Syndrome Phenotype |
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