TWO NEW TRICHOTHECENES, PD 113, 325 AND PD 113, 326

Two new trichothecenes, PD 113, 325 and PD 113, 326, were isolated and their structures were shown to be 12'-hydroxy-2'-(E)-verrucarin J (1a) and a stereoisomer of satratoxin H (3).

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Bibliographic Details
Published in:Journal of antibiotics 1984, Vol.37(8), pp.823-828
Main Authors: SMITKA, T. A., BUNGE, R. H., BLOEM, R. J., FRENCH, J. C.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents
Biological and medical sciences
General pharmacology
Leukemia P388 - drug therapy
Magnetic Resonance Spectroscopy
Medical sciences
Mice
Myrothecium
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Sesquiterpenes - isolation & purification
Stereoisomerism
Trichothecenes - analysis
Trichothecenes - isolation & purification
Trichothecenes - therapeutic use
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Description
Summary:Two new trichothecenes, PD 113, 325 and PD 113, 326, were isolated and their structures were shown to be 12'-hydroxy-2'-(E)-verrucarin J (1a) and a stereoisomer of satratoxin H (3).
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.37.823