Patterns of recurrence of gastrointestinal stromal tumour (GIST) following complete resection: Implications for follow-up

Aim To determine the frequency, time course and sites of recurrence following surgical resection of gastrointestinal stromal tumours (GIST) and to evaluate the performance of a risk-based surveillance protocol in detection of recurrence. Methods Eighty-one patients on surveillance following complete...

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Bibliographic Details
Published in:Clinical radiology 2013-08, Vol.68 (8), p.770-775
Main Authors: Plumb, A.A, Kochhar, R, Leahy, M, Taylor, M.B
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Contrast Media
Female
Follow-Up Studies
Gastrointestinal Stromal Tumors - diagnostic imaging
Gastrointestinal Stromal Tumors - pathology
Gastrointestinal Stromal Tumors - surgery
Humans
Iohexol
Male
Middle Aged
Neoplasm Recurrence, Local - diagnostic imaging
Neoplasm Recurrence, Local - pathology
Population Surveillance
Radiology
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
Tomography, X-Ray Computed
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Summary:Aim To determine the frequency, time course and sites of recurrence following surgical resection of gastrointestinal stromal tumours (GIST) and to evaluate the performance of a risk-based surveillance protocol in detection of recurrence. Methods Eighty-one patients on surveillance following complete resection of GIST were included. Patients were stratified into risk groups according to accepted histopathological criteria. Computed tomography (CT) examinations were retrospectively reviewed to determine rates, sites and imaging characteristics of recurrence and to assess compliance with the local follow-up protocol. Results The median time of follow-up was 41 months. Nineteen patients suffered recurrence, all of whom were in the high-risk group. Fifty-eight percent of relapses occurred within 1 year and 84% within 3 years. Even within the high-risk group, patients with relapse had significantly larger (mean 15 versus 10.4 cm, p  
ISSN:0009-9260
1365-229X
DOI:10.1016/j.crad.2013.03.002