IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects

Highlights • Significantly association found IL-4 gene 70 bp VNTR polymorphism and MTHFR C677T polymorphism with development of RA. • MTHFR / IL-4 CCP2 P2 combine genotype was estimated to have protective effect against RA. • We found that there was a difference between MTHFR genotypes and ocular in...

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Bibliographic Details
Published in:Immunology letters 2013-05, Vol.152 (2), p.104-108
Main Authors: Inanir, Ahmet, Yigit, Serbulent, Tekcan, Akın, Tural, Sengul, Kismali, Gorkem
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Arthritis, Rheumatoid - genetics
Female
Gene Frequency
Genetic Markers
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-4 - genetics
Interleukin-4 gene (IL-4)
Male
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Methylenetetrahydrofolate reductase gene (MTHFR)
Middle Aged
Minisatellite Repeats - genetics
Polymorphism
Polymorphism, Single Nucleotide
Rheumatiod arthritis
Risk Factors
Turkey
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Summary:Highlights • Significantly association found IL-4 gene 70 bp VNTR polymorphism and MTHFR C677T polymorphism with development of RA. • MTHFR / IL-4 CCP2 P2 combine genotype was estimated to have protective effect against RA. • We found that there was a difference between MTHFR genotypes and ocular involvement in patients with RA.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2013.05.004