IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects

Highlights • Significantly association found IL-4 gene 70 bp VNTR polymorphism and MTHFR C677T polymorphism with development of RA. • MTHFR / IL-4 CCP2 P2 combine genotype was estimated to have protective effect against RA. • We found that there was a difference between MTHFR genotypes and ocular in...

Full description

Saved in:
Bibliographic Details
Published in:Immunology letters 2013-05, Vol.152 (2), p.104-108
Main Authors: Inanir, Ahmet, Yigit, Serbulent, Tekcan, Akın, Tural, Sengul, Kismali, Gorkem
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Arthritis, Rheumatoid - genetics
Female
Gene Frequency
Genetic Markers
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-4 - genetics
Interleukin-4 gene (IL-4)
Male
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Methylenetetrahydrofolate reductase gene (MTHFR)
Middle Aged
Minisatellite Repeats - genetics
Polymorphism
Polymorphism, Single Nucleotide
Rheumatiod arthritis
Risk Factors
Turkey
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c414t-e72c7a3c9eb18d24a5831928d8c6b8c46ba3a9dba7488237c67066f76b2a28743
cites cdi_FETCH-LOGICAL-c414t-e72c7a3c9eb18d24a5831928d8c6b8c46ba3a9dba7488237c67066f76b2a28743
container_end_page 108
container_issue 2
container_start_page 104
container_title Immunology letters
container_volume 152
creator Inanir, Ahmet
Yigit, Serbulent
Tekcan, Akın
Tural, Sengul
Kismali, Gorkem
description Highlights • Significantly association found IL-4 gene 70 bp VNTR polymorphism and MTHFR C677T polymorphism with development of RA. • MTHFR / IL-4 CCP2 P2 combine genotype was estimated to have protective effect against RA. • We found that there was a difference between MTHFR genotypes and ocular involvement in patients with RA.
doi_str_mv 10.1016/j.imlet.2013.05.004
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1399055073</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0165247813000643</els_id><sourcerecordid>1399055073</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-e72c7a3c9eb18d24a5831928d8c6b8c46ba3a9dba7488237c67066f76b2a28743</originalsourceid><addsrcrecordid>eNqFkctq3EAQRRuTYI8fX2AIWmYjpfrdWjgQjF9hQiC2102rVfL0RI9Jt2SYv7fGY2eRTVa1ObeKOpeQcwoFBaq-rIvQtTgWDCgvQBYA4oAsqNFlDlKwD2QxUzJnQpsjcpzSGoBKLvghOWJcGcmkXpDvd8tcZK6vsx8Pt9e_sifsMdsM7bYb4mYVUpeFPosrnDo3DqHOXBxXMYwhvWbGFYaYYdOgH9Mp-di4NuHZ2zwhj9dXD5e3-fLnzd3lt2XuBRVjjpp57bgvsaKmZsJJw2nJTG28qowXqnLclXXltDCGce2VBqUarSrmmNGCn5DP-72bOPyZMI22C8lj27oehylZyssSpATNZ5TvUR-HlCI2dhND5-LWUrA7iXZtXyXanUQL0s4S59SntwNT1WH9N_NubQYu9gDObz4HjDb5gL3HOsTZhK2H8J8DX__J-zb0wbv2N24xrYcp9rNBS21iFuz9rsddjZQDgBKcvwAfsZcn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1399055073</pqid></control><display><type>article</type><title>IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects</title><source>ScienceDirect Freedom Collection</source><creator>Inanir, Ahmet ; Yigit, Serbulent ; Tekcan, Akın ; Tural, Sengul ; Kismali, Gorkem</creator><creatorcontrib>Inanir, Ahmet ; Yigit, Serbulent ; Tekcan, Akın ; Tural, Sengul ; Kismali, Gorkem</creatorcontrib><description>Highlights • Significantly association found IL-4 gene 70 bp VNTR polymorphism and MTHFR C677T polymorphism with development of RA. • MTHFR / IL-4 CCP2 P2 combine genotype was estimated to have protective effect against RA. • We found that there was a difference between MTHFR genotypes and ocular involvement in patients with RA.</description><identifier>ISSN: 0165-2478</identifier><identifier>EISSN: 1879-0542</identifier><identifier>DOI: 10.1016/j.imlet.2013.05.004</identifier><identifier>PMID: 23685257</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Allergy and Immunology ; Arthritis, Rheumatoid - genetics ; Female ; Gene Frequency ; Genetic Markers ; Genetic Predisposition to Disease ; Genotype ; Humans ; Interleukin-4 - genetics ; Interleukin-4 gene (IL-4) ; Male ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Methylenetetrahydrofolate reductase gene (MTHFR) ; Middle Aged ; Minisatellite Repeats - genetics ; Polymorphism ; Polymorphism, Single Nucleotide ; Rheumatiod arthritis ; Risk Factors ; Turkey</subject><ispartof>Immunology letters, 2013-05, Vol.152 (2), p.104-108</ispartof><rights>Elsevier B.V.</rights><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-e72c7a3c9eb18d24a5831928d8c6b8c46ba3a9dba7488237c67066f76b2a28743</citedby><cites>FETCH-LOGICAL-c414t-e72c7a3c9eb18d24a5831928d8c6b8c46ba3a9dba7488237c67066f76b2a28743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23685257$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inanir, Ahmet</creatorcontrib><creatorcontrib>Yigit, Serbulent</creatorcontrib><creatorcontrib>Tekcan, Akın</creatorcontrib><creatorcontrib>Tural, Sengul</creatorcontrib><creatorcontrib>Kismali, Gorkem</creatorcontrib><title>IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects</title><title>Immunology letters</title><addtitle>Immunol Lett</addtitle><description>Highlights • Significantly association found IL-4 gene 70 bp VNTR polymorphism and MTHFR C677T polymorphism with development of RA. • MTHFR / IL-4 CCP2 P2 combine genotype was estimated to have protective effect against RA. • We found that there was a difference between MTHFR genotypes and ocular involvement in patients with RA.</description><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Markers</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Interleukin-4 - genetics</subject><subject>Interleukin-4 gene (IL-4)</subject><subject>Male</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Methylenetetrahydrofolate reductase gene (MTHFR)</subject><subject>Middle Aged</subject><subject>Minisatellite Repeats - genetics</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Rheumatiod arthritis</subject><subject>Risk Factors</subject><subject>Turkey</subject><issn>0165-2478</issn><issn>1879-0542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkctq3EAQRRuTYI8fX2AIWmYjpfrdWjgQjF9hQiC2102rVfL0RI9Jt2SYv7fGY2eRTVa1ObeKOpeQcwoFBaq-rIvQtTgWDCgvQBYA4oAsqNFlDlKwD2QxUzJnQpsjcpzSGoBKLvghOWJcGcmkXpDvd8tcZK6vsx8Pt9e_sifsMdsM7bYb4mYVUpeFPosrnDo3DqHOXBxXMYwhvWbGFYaYYdOgH9Mp-di4NuHZ2zwhj9dXD5e3-fLnzd3lt2XuBRVjjpp57bgvsaKmZsJJw2nJTG28qowXqnLclXXltDCGce2VBqUarSrmmNGCn5DP-72bOPyZMI22C8lj27oehylZyssSpATNZ5TvUR-HlCI2dhND5-LWUrA7iXZtXyXanUQL0s4S59SntwNT1WH9N_NubQYu9gDObz4HjDb5gL3HOsTZhK2H8J8DX__J-zb0wbv2N24xrYcp9rNBS21iFuz9rsddjZQDgBKcvwAfsZcn</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Inanir, Ahmet</creator><creator>Yigit, Serbulent</creator><creator>Tekcan, Akın</creator><creator>Tural, Sengul</creator><creator>Kismali, Gorkem</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130501</creationdate><title>IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects</title><author>Inanir, Ahmet ; Yigit, Serbulent ; Tekcan, Akın ; Tural, Sengul ; Kismali, Gorkem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-e72c7a3c9eb18d24a5831928d8c6b8c46ba3a9dba7488237c67066f76b2a28743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Markers</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Interleukin-4 - genetics</topic><topic>Interleukin-4 gene (IL-4)</topic><topic>Male</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Methylenetetrahydrofolate reductase gene (MTHFR)</topic><topic>Middle Aged</topic><topic>Minisatellite Repeats - genetics</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Rheumatiod arthritis</topic><topic>Risk Factors</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inanir, Ahmet</creatorcontrib><creatorcontrib>Yigit, Serbulent</creatorcontrib><creatorcontrib>Tekcan, Akın</creatorcontrib><creatorcontrib>Tural, Sengul</creatorcontrib><creatorcontrib>Kismali, Gorkem</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inanir, Ahmet</au><au>Yigit, Serbulent</au><au>Tekcan, Akın</au><au>Tural, Sengul</au><au>Kismali, Gorkem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects</atitle><jtitle>Immunology letters</jtitle><addtitle>Immunol Lett</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>152</volume><issue>2</issue><spage>104</spage><epage>108</epage><pages>104-108</pages><issn>0165-2478</issn><eissn>1879-0542</eissn><abstract>Highlights • Significantly association found IL-4 gene 70 bp VNTR polymorphism and MTHFR C677T polymorphism with development of RA. • MTHFR / IL-4 CCP2 P2 combine genotype was estimated to have protective effect against RA. • We found that there was a difference between MTHFR genotypes and ocular involvement in patients with RA.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23685257</pmid><doi>10.1016/j.imlet.2013.05.004</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0165-2478
ispartof Immunology letters, 2013-05, Vol.152 (2), p.104-108
issn 0165-2478
1879-0542
language eng
recordid cdi_proquest_miscellaneous_1399055073
source ScienceDirect Freedom Collection
subjects Adult
Allergy and Immunology
Arthritis, Rheumatoid - genetics
Female
Gene Frequency
Genetic Markers
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-4 - genetics
Interleukin-4 gene (IL-4)
Male
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Methylenetetrahydrofolate reductase gene (MTHFR)
Middle Aged
Minisatellite Repeats - genetics
Polymorphism
Polymorphism, Single Nucleotide
Rheumatiod arthritis
Risk Factors
Turkey
title IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T01%3A11%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=IL-4%20and%20MTHFR%20gene%20polymorphism%20in%20rheumatoid%20arthritis%20and%20their%20effects&rft.jtitle=Immunology%20letters&rft.au=Inanir,%20Ahmet&rft.date=2013-05-01&rft.volume=152&rft.issue=2&rft.spage=104&rft.epage=108&rft.pages=104-108&rft.issn=0165-2478&rft.eissn=1879-0542&rft_id=info:doi/10.1016/j.imlet.2013.05.004&rft_dat=%3Cproquest_cross%3E1399055073%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c414t-e72c7a3c9eb18d24a5831928d8c6b8c46ba3a9dba7488237c67066f76b2a28743%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1399055073&rft_id=info:pmid/23685257&rfr_iscdi=true