Beclin 1 and bcl-2 expressions in bladder urothelial tumors and their association with clinicopathological parameters

Beclin 1 plays a critical role in the regulation of autophagy, apoptosis, differentiation, as well as in the development and progression of cancer. The aim of this study was to examine the expression of beclin 1 and bcl-2 in bladder urothelial tumors, and to investigate the relationship between thes...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2013-07, Vol.209 (7), p.418-423
Main Authors: Baspinar, Sirin, Bircan, Sema, Yavuz, Gulcan, Kapucuoglu, Nilgun
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Apoptosis Regulatory Proteins - analysis
Bcl-2
Beclin 1
Biomarkers, Tumor - analysis
Bladder urothelial tumor
Chi-Square Distribution
Down-Regulation
Female
Humans
Immunohistochemistry
Male
Membrane Proteins - analysis
Middle Aged
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Staging
Predictive Value of Tests
Prognosis
Proto-Oncogene Proteins c-bcl-2 - analysis
Tissue Array Analysis
Up-Regulation
Urinary Bladder Neoplasms - chemistry
Urinary Bladder Neoplasms - pathology
Urothelium - chemistry
Urothelium - pathology
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Summary:Beclin 1 plays a critical role in the regulation of autophagy, apoptosis, differentiation, as well as in the development and progression of cancer. The aim of this study was to examine the expression of beclin 1 and bcl-2 in bladder urothelial tumors, and to investigate the relationship between these two markers and clinicopathological parameters. Our study included 84 bladder urothelial tumors and 10 non-tumoral bladder tissues. Immunohistochemistry was performed on tissue microarray (TMA) sections and was evaluated semiquantitatively on the basis of the percentage of positively stained cells (proportion) and staining intensity. A significant association was found between the expression score of beclin 1 and pT stages of the urothelial tumors (p=0.012). Also, the level of beclin 1 expression inversely correlated with histological grade and pT stages (p=0.009, r=−0.284; p=0.001, r=−0.361, respectively). The bcl-2 expression level positively correlated with histological grade and pT stages of the urothelial tumors (p=0.026, r=0.243; p
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2013.04.006