A new sesquiterpene lactone from Sarcandra glabra

A new eudesmanolide sesquiterpene, atractylenolide IV (1), together with seven known compounds were isolated from the 70% aqueous acetonic extract of the whole plant of Sarcandra glabra (Chloranthaceae). Their structures were established by spectral analysis, mainly UV, IR, HRESI-MS, 1D and 2D-NMR e...

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Bibliographic Details
Published in:Natural product research 2013-07, Vol.27 (13), p.1197-1201
Main Authors: Hu, Xiao-Ru, Wu, Hai-Feng, Zhang, Xiao-Po, Yang, Jun-Shan, Dai, Zhong, Lin, Rui-Chao, Xu, Xu-Dong
Format: Article
Language:English
Subjects:
atractylenolide IV
chloranthaceae
cytotoxic activity
Lactones - chemistry
Magnoliopsida - chemistry
Sarcandra glabra
sesquiterpene
Sesquiterpenes - chemistry
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Summary:A new eudesmanolide sesquiterpene, atractylenolide IV (1), together with seven known compounds were isolated from the 70% aqueous acetonic extract of the whole plant of Sarcandra glabra (Chloranthaceae). Their structures were established by spectral analysis, mainly UV, IR, HRESI-MS, 1D and 2D-NMR experiments (HSQC, HMBC and NOESY). Compounds 1-4 showed no remarkable cytotoxic activity against Hela, HCT-8 and MCF-7 cancer cell lines with IC 50  > 50 µg mL −1 .
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2012.722084