Retrospective evaluation of the effectiveness of epsilon aminocaproic acid for the prevention of postamputation bleeding in retired racing Greyhounds with appendicular bone tumors: 46 cases (2003–2008)

• Published in: Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000) Tex. : 2000), 2012-06, Vol.22 (3), p.332-340
• Main Authors: Marín, Liliana M, Iazbik, M. Cristina, Zaldivar‐Lopez, Sara, Lord, Linda K, Stingle, Nicole, Vilar, Paulo, Lara‐Garcia, Ana, Alvarez, Francisco, Hosoya, Kenji, Nelson, Laura, Pozzi, Antonio, Cooper, Edward, McLoughlin, Mary A, Ball, Rebecca, Kisseberth, William C, London, Cheryl A, Dudley, Robert, Dyce, Jonathan, McMahon, Melanie, Lerche, Phillip, Bednarski, Richard, Couto, C. Guillermo
• Format: Article
• Language: English
• Subjects: Aminocaproic Acid - therapeutic use; amputation; Amputation - adverse effects; Amputation - veterinary; Animals; Antifibrinolytic Agents - therapeutic use; blood; Bone Neoplasms - surgery; Bone Neoplasms - veterinary; coagulation; dog; Dog Diseases - genetics; Dog Diseases - prevention & control; Dog Diseases - surgery; Dogs; Genetic Predisposition to Disease; Greyhound; hemorrhage; Hemorrhage - genetics; Hemorrhage - prevention & control; Hemorrhage - veterinary; neoplasms; osteosarcoma; Osteosarcoma - surgery; Osteosarcoma - veterinary; postoperative complications; Postoperative Complications - prevention & control; Postoperative Complications - veterinary; prospective studies; regression analysis; Retrospective Studies
• ISSN: 1479-3261; 1476-4431
• DOI: 10.1111/j.1476-4431.2012.00735.x

OBJECTIVES: To determine the frequency of delayed postoperative bleeding in retired racing Greyhounds with appendicular bone tumors undergoing limb amputations. To identify if administration of epsilon‐aminocaproic acid (EACA) was effective on the prevention of postoperative bleeding. DESIGN: Retrospective study from December 2003 to December 2008. SETTING: Veterinary university teaching hospital. ANIMALS: Forty‐six retired racing Greyhounds (RRGs) diagnosed with primary appendicular bone tumors that underwent limb amputation were included in the study. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Thirteen of 46 RRGs (28%) included in the study had delayed postoperative bleeding starting 48–72 h after surgery. Bleeding episodes included cutaneous, subcutaneous, and external bleeding that extended from the area of the surgical site that became widespread within hours, and that required administration of blood components. A paired t‐test suggests that there was a significant decrease in PCV postoperatively for both dogs that bled and dogs that did not bleed (P < 0.0001). Forty of 46 RRGs (86%) received either fresh frozen plasma (FFP) or EACA or both, for the prevention of postoperative bleeding. A logistic regression model determined that dogs that did not receive EACA were 5.7 times more likely to bleed than dogs that did receive EACA, when controlling for whether or not they received FFP (95% CI: 1.02–32.15, P = 0.047). CONCLUSION: This retrospective study suggests that preemptive postoperative administration of EACA appears to be efficacious in decreasing the frequency of bleeding in RRGs undergoing limb amputation; however, a prospective study is warranted to corroborate its effectiveness.