Ionic liquids as ingredients in topical drug delivery systems

Because of their properties, ionic liquids (ILs) (Ranke et al.) offer many advantages in topical drug delivery systems. For example, ionic liquids can be used to increase the solubility of sparingly soluble drugs and to enhance their topical and transdermal delivery. Furthermore, ILs can be used eit...

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Bibliographic Details
Published in:International journal of pharmaceutics 2013-01, Vol.441 (1-2), p.620-627
Main Authors: Dobler, Dorota, Schmidts, Thomas, Klingenhöfer, Ines, Runkel, Frank
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
anti-infective properties
Antimicrobial activity
cytotoxicity
Drug Delivery Systems
Drug Stability
drugs
emulsifying properties
Emulsion stability
Emulsions
fluorescence
Fluorescent Dyes - administration & dosage
Fluorescent Dyes - pharmacokinetics
Humans
hydrophilicity
Hydrophobic and Hydrophilic Interactions
hydrophobicity
in vitro studies
ingredients
Ionic liquids
Ionic Liquids - chemistry
Ionic Liquids - pharmacology
Penetration enhancement
preservatives
Preservatives, Pharmaceutical - chemistry
Preservatives, Pharmaceutical - pharmacology
Skin Absorption
Solubility
Swine
Toxicity Tests
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Summary:Because of their properties, ionic liquids (ILs) (Ranke et al.) offer many advantages in topical drug delivery systems. For example, ionic liquids can be used to increase the solubility of sparingly soluble drugs and to enhance their topical and transdermal delivery. Furthermore, ILs can be used either to synthesize active pharmaceutical ingredients or as antimicrobial ingredients. In the present work, the conventional oil-in-water (O/W) and water-in-oil (W/O) emulsions containing the hydrophilic IL [HMIM] [Cl] and the hydrophobic IL [BMIM] [PF6] were prepared, and the influence of the ILs on emulsion properties was evaluated. It was found that ILs could be successfully incorporated into the emulsion structure, resulting in stable formulations. The antimicrobial activity of ILs in the formulations was estimated, and their application as preservatives was confirmed by performing preservative efficacy tests. Evaluation of the in vitro cytotoxicity of the emulsions containing hydrophilic or hydrophobic ILs showed the low cytotoxicity of the carriers. Finally, penetration enhancement of a fluorescent dye as a model drug in the presence of ionic liquids was shown.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2012.10.035