Omega 3 Fatty Acids Promote Macrophage Reverse Cholesterol Transport in Hamster Fed High Fat Diet. e61109

The aim of this study was to investigate macrophage reverse cholesterol transport (RCT) in hamster, a CETP-expressing species, fed omega 3 fatty acids ( omega 3PUFA) supplemented high fat diet (HFD). Three groups of hamsters (n = 6/group) were studied for 20 weeks: 1) control diet: Control, 2) HFD g...

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Bibliographic Details
Published in:PloS one 2013-04, Vol.8 (4)
Main Authors: Chadli, Fatima Kasbi, Nazih, Hassane, Krempf, Michel, Nguyen, Patrick, Ouguerram, Khadija
Format: Article
Language:English
Subjects:
ABCA1 protein
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Summary:The aim of this study was to investigate macrophage reverse cholesterol transport (RCT) in hamster, a CETP-expressing species, fed omega 3 fatty acids ( omega 3PUFA) supplemented high fat diet (HFD). Three groups of hamsters (n = 6/group) were studied for 20 weeks: 1) control diet: Control, 2) HFD group: HF and 3) HFD group supplemented with omega 3PUFA (EPA and DHA): HF omega 3. In vivo macrophage-to-feces RCT was assessed after an intraperitoneal injection of 3H-cholesterol-labelled hamster primary macrophages. Compared to Control, HF presented significant (p
ISSN:1932-6203
DOI:10.1371/journal.pone.0061109