Antiparasitic agents: new drugs on the horizon

Highlights ► New drug candidates are being clinically tested against malaria and sleeping sickness. ► For malaria these are the synthetic peroxide OZ439 and the spiroindolone NITD609. ► For sleeping sickness these are fexinidazole and the benzoxaborole SCYX-7158. ► Novel diamidines were identified t...

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Bibliographic Details
Published in:Current opinion in pharmacology 2012-10, Vol.12 (5), p.562-566
Main Authors: Mäser, Pascal, Wittlin, Sergio, Rottmann, Matthias, Wenzler, Tanja, Kaiser, Marcel, Brun, Reto
Format: Article
Language:English
Subjects:
Animals
Antiparasitic Agents - pharmacology
Antiparasitic Agents - therapeutic use
Humans
Internal Medicine
Malaria - drug therapy
Medical Education
Plasmodium falciparum
Plasmodium falciparum - drug effects
Trypanosoma brucei
Trypanosoma brucei brucei - drug effects
Trypanosomiasis, African - drug therapy
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Summary:Highlights ► New drug candidates are being clinically tested against malaria and sleeping sickness. ► For malaria these are the synthetic peroxide OZ439 and the spiroindolone NITD609. ► For sleeping sickness these are fexinidazole and the benzoxaborole SCYX-7158. ► Novel diamidines were identified that cure sleeping sickness in animal models.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2012.05.001