Synthesis of (-)-arctigenin derivatives and their anticancer activity

The natural dibenzylbutyrolactone type lignanolide (-)-arctigenin, which was prepared from fructus arctii, showed obvious anticancer activity. The synthesis of four new (-)-arctigenin derivatives and their anticancer bioactivities were examined. The structures of the four new synthetic derivatives w...

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Bibliographic Details
Published in:Natural product research 2012-01, Vol.26 (2), p.177-181
Main Authors: Gui-Rong, Chen, Li-Ping, Cai, De-Qiang, Dou, Ting-Guo, Kang, Hong-Fu, Li, Fu-Rui, Li, Ning, Jiang
Format: Article
Language:English
Subjects:
(-)-arctigenin
Alkylation
anticancer bioactivity
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Arctium - chemistry
Butylamines - chemistry
Cell Line, Tumor
Cell Survival - drug effects
Ethylamines - chemistry
Fruit - chemistry
Furans - analysis
Furans - chemistry
Furans - pharmacology
Humans
Inhibitory Concentration 50
Lignans - analysis
Lignans - chemistry
Lignans - pharmacology
Methylamines - chemistry
Molecular Structure
synthesis
synthetic derivatives
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Summary:The natural dibenzylbutyrolactone type lignanolide (-)-arctigenin, which was prepared from fructus arctii, showed obvious anticancer activity. The synthesis of four new (-)-arctigenin derivatives and their anticancer bioactivities were examined. The structures of the four new synthetic derivatives were elucidated.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2010.541874