Bactericidal Activity of Lachrymal Secretion and Complement System in Copper Deficient Bovines

Copper deficiency in humans and animals has been related to increased susceptibility to infections. Neutrophils are one of the most studied components of the immune response; however, to the best of our knowledge, other defenses of the innate immune system have not been analyzed in copper-deficient...

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Bibliographic Details
Published in:Biological trace element research 2013-06, Vol.153 (1-3), p.178-183
Main Authors: Postma, Gabriela C, Minatel, Leonardo, Olivares, Roberto W. I, Schapira, Andrea, Dallorso, Maria E, Carfagnini, Julio C
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
antibacterial properties
Bacteria
Bactericidal activity
Biochemistry
Biomedical and Life Sciences
Biotechnology
calves
Cattle
complement
Complement System Proteins
Copper
Copper - deficiency
defense mechanisms
humans
Immune response
Immune system
innate immunity
keratoconjunctivitis
Keratoconjunctivitis, Infectious - immunology
Lacrimal Apparatus - secretion
Life Sciences
Moraxella bovis
neutrophils
Nutrition
Oncology
secretion
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Summary:Copper deficiency in humans and animals has been related to increased susceptibility to infections. Neutrophils are one of the most studied components of the immune response; however, to the best of our knowledge, other defenses of the innate immune system have not been analyzed in copper-deficient animals. Our previous studies in copper-deficient bovines have shown increased susceptibility to infectious keratoconjunctivitis, an ocular disease caused by Moraxella bovis. The objective of this work was to evaluate the bactericidal activity of lachrymal secretion and complement system, two main mechanisms of the innate immune response against M. bovis, in copper-deficient cattle. Our results indicate that copper deficiency has no effect on bactericidal activity of complement system and lachrymal secretion against M. bovis in calves. Other components of local and systemic ocular defense mechanisms that could explain the increased susceptibility to infectious keratoconjunctivitis observed in copper-deficient bovines should be investigated.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-013-9664-1