Clonal succession in the hemopoietic system: Number of primitive hemopoietic stem cells and clone lifespan

The fate of individual primitive hemopoietic stem cells is studied by retroviral gene transfer technique. Tens of small hemopoietic clones with a lifespan no longer than 1 month simultaneously function throughout life in lethally irradiated mice reconstituted with bone marrow cells. The disappearing...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1999-04, Vol.127 (4), p.381-385
Main Authors: Drize, N. I., Todriya, T. V., Chertkov, I. L.
Format: Article
Language:English
Subjects:
Bone marrow
Stem cells
Transplants & implants
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Summary:The fate of individual primitive hemopoietic stem cells is studied by retroviral gene transfer technique. Tens of small hemopoietic clones with a lifespan no longer than 1 month simultaneously function throughout life in lethally irradiated mice reconstituted with bone marrow cells. The disappearing clones are not detected again, which confirms the clonal succession. The number of primitive hemopoietic stem cells in mouse bone marrow has been directly estimated: 1 per 8000 hemopoietic cells, or 30×10^sup 3^ per mouse, which is at least ten times higher than expected.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02433387