Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strains

Chagasic cardiopathy has become one of the most frequent causes of heart failure and sudden death, as well as one of the most common causes of cardio-embolic stroke in Latin America. The myocyte response to oxidative stress involves the progression of cellular changes, primarily targeting the mitoch...

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Bibliographic Details
Published in:Parasitology 2013-03, Vol.140 (3), p.414-421
Main Authors: BÁEZ, ALEJANDRA LIDIA, LO PRESTI, MARÍA SILVINA, FRETES, RICARDO, DÍAZ, CINTIA, PONS, PATRICIA, BAZÁN, PAOLA CAROLINA, STRAUSS, MARIANA, RIVAROLA, HÉCTOR WALTER, PAGLINI-OLIVA, PATRICIA
Format: Article
Language:English
Subjects:
Animals
Chagas Cardiomyopathy - parasitology
Chagas Cardiomyopathy - pathology
Chagas Cardiomyopathy - physiopathology
Chagas Disease - parasitology
Chagas Disease - pathology
Chagas Disease - physiopathology
Chronic Disease
Citrate (si)-Synthase - metabolism
Disease Models, Animal
Disease Progression
Electrocardiography
Female
Heart - parasitology
Heart - physiopathology
Heart failure
Host-Parasite Interactions
Humans
Laboratory animals
Male
Mice
Mitochondria
Mitochondria - enzymology
Mitochondria - parasitology
Mitochondria - pathology
Myocardium - metabolism
Myocardium - pathology
Nitric oxide
Oxidative stress
Parasitemia - parasitology
Parasitemia - physiopathology
Parasites
Patients
Rodents
Species Specificity
Trypanosoma cruzi
Trypanosoma cruzi - classification
Trypanosoma cruzi - pathogenicity
Vector-borne diseases
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Summary:Chagasic cardiopathy has become one of the most frequent causes of heart failure and sudden death, as well as one of the most common causes of cardio-embolic stroke in Latin America. The myocyte response to oxidative stress involves the progression of cellular changes, primarily targeting the mitochondria and modifying therefore the energy supply. In this paper we analysed the effect of the infection of mice with 2 different strains of Trypanosoma cruzi (Tulahuen and SGO Z12) in the chronic indeterminate stage (75 days post-infection), upon the structure and function of cardiac mitochondria. The structural results showed that 83% of the mitochondria from the Tulahuen-infected mice presented an increase in their matrix and 91% of the mitochondria from the SGO Z12-infected group showed a reduction in their diameter (P 
ISSN:0031-1820
1469-8161
1469-8161
DOI:10.1017/S0031182012001771