Inflammatory immune cell responses and Toll-like receptor expression in synovial tissues in rheumatoid arthritis patients treated with biologics or DMARDs

Biologic antirheumatic drugs (BIO) have been reported to be potent therapeutic agents in the prevention of inflammatory joint destruction in rheumatoid arthritis (RA). The aim of this study was to investigate the immune-inflammatory cells, including Toll-like receptor (TLR)-equipped cells, in synovi...

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Bibliographic Details
Published in:Clinical rheumatology 2013-06, Vol.32 (6), p.853-861
Main Authors: Takakubo, Yuya, Tamaki, Yasunobu, Hirayama, Tomoyuki, Iwazaki, Kiyoshi, Sasaki, Kan, Sasaki, Akiko, Ohki, Hiroharu, Takakubo, Noe, Konttinen, Yrjö T., Takagi, Michiaki
Format: Article
Language:English
Subjects:
Aged
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - immunology
Biological Products - therapeutic use
Dendritic Cells - cytology
Female
Humans
Immunohistochemistry
Inflammation - immunology
Inflammation - pathology
Macrophages - cytology
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Rheumatology
Synovial Fluid - immunology
Synovial Membrane - metabolism
Synovitis - metabolism
Toll-Like Receptors - metabolism
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Summary:Biologic antirheumatic drugs (BIO) have been reported to be potent therapeutic agents in the prevention of inflammatory joint destruction in rheumatoid arthritis (RA). The aim of this study was to investigate the immune-inflammatory cells, including Toll-like receptor (TLR)-equipped cells, in synovial tissue samples from RA patients on BIO compared to patients, who are only on conventional disease-modifying antirheumatic drug (DMARD). We analyzed immune-inflammatory cells in RA synovitis in patients of BIO group ( n  = 20) or DMARD group ( n  = 20). The grading scores of synovitis was 1.7 and 1.8 in each BIO and DMARD group and correlated best with the CD3 + T ( r  = 0.71/0.70, p  
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-013-2209-3