Design and synthesis of beta -amino alcohol based beta -lactam-isatin chimeras and preliminary analysis of in vitroactivity against the protozoal pathogen Trichomonas vaginalis

We have described the synthesis of beta -amino alcohol based beta -lactam-isatin chimeras along with their in vitroevaluation against T. vaginalis. SAR studies showed dependence of activity on concentration as well as substituent on N-1 of beta -lactam and C-5 of isatin with preference for a chloro-...

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Bibliographic Details
Published in:MedChemComm 2013-05, Vol.4 (6), p.1018-1024
Main Authors: Mehra, Vishu, Hopper, Melissa, Patel, Neal, Hall, Dominique, Wrischnik, Lisa A, Land, Kirkwood M, Kumar, Vipan
Format: Article
Language:English
Subjects:
Trichomonas vaginalis
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Summary:We have described the synthesis of beta -amino alcohol based beta -lactam-isatin chimeras along with their in vitroevaluation against T. vaginalis. SAR studies showed dependence of activity on concentration as well as substituent on N-1 of beta -lactam and C-5 of isatin with preference for a chloro-substituent for good activity.
ISSN:2040-2503
2040-2511
DOI:10.1039/c3md00057e