Allergic disease in the first year of life is associated with differences in subsequent neurodevelopment and behaviour

• Published in: Early human development 2012-07, Vol.88 (7), p.567-573
• Main Authors: Meldrum, Suzanne J, D'Vaz, Nina, Dunstan, Janet A, Mori, Trevor A, Hird, Kathryn, Simmer, Karen, Prescott, Susan L
• Format: Article
• Language: English
• Subjects: Adult; Advanced Basic Science; Age of Onset; Allergic disease; Biological and medical sciences; Brain - growth & development; Brain - physiology; Child Development - drug effects; Child Development - physiology; Embryology: invertebrates and vertebrates. Teratology; Female; Fish Oils - administration & dosage; Fish Oils - adverse effects; Food Hypersensitivity - etiology; Food Hypersensitivity - immunology; Fundamental and applied biological sciences. Psychology; Humans; Hypersensitivity - complications; Hypersensitivity - epidemiology; Hypersensitivity - etiology; Hypersensitivity - physiopathology; Infancy; Infant; Infant Behavior - drug effects; Infant Behavior - physiology; Infant Behavior - psychology; Infant, Newborn; Male; Neonatal and Perinatal Medicine; Neurodevelopment; Olive Oil; Plant Oils - administration & dosage; Plant Oils - adverse effects; Pregnancy; Pregnancy Complications - epidemiology; Pregnancy Complications - immunology; Prenatal Exposure Delayed Effects - epidemiology; Prenatal Exposure Delayed Effects - immunology; Prenatal Exposure Delayed Effects - physiopathology
• ISSN: 0378-3782; 1872-6232
• DOI: 10.1016/j.earlhumdev.2011.12.032

Abstract Background Recent trials suggest a link between neuropsychological function, atopy and allergic disease particularly in early childhood; however the nature of this association remains unclear. Aims To investigate the relationship between early allergic disease and sensitisation at 12 months of age and neurodevelopmental outcomes at 18 months. Study design Linear or binary logistic regression analysis was used to determine whether allergic diseases or sensitization at 12 months of age was a significant predictor of neurodevelopmental test scores at the 18 months. Subjects Infants with a maternal history of allergic disease (n = 324). Outcome measures Allergic outcomes at 12 months of age included allergen sensitisation, eczema, IgE-mediated and food allergy, and neurodevelopmental outcomes at 18 included the Bayley Scales of Infant Toddler Development III Edition, the Achenbach Child Behaviour Checklist and the Macarthur Scales of Infant Toddler Development. Results Children with any diagnosed allergic disease at 12 months had evidence of reduced motor scores ( p = .016), and this was most apparent for a diagnosis of eczema ( p = .007). Non-IgE mediated food allergy was significantly positively associated with problem Internalising Behaviours ( p = .010), along with a trend for effects on the Social–Emotional composite score for IgE-Mediated food allergies ( p = .052). Allergic sensitisation was not independently associated with any effects on neurodevelopmental outcomes. Conclusion This study provides evidence that an allergic phenotype in infancy is associated with effects on neurodevelopment. Further research is required to investigate the nature of this relationship.