Association of L-Ficolin Levels and FCN2 Genotypes with Chronic Chagas Disease. e60237

Background L-ficolin (encoded by FCN2) binds to acetylated sugar moieties of many pathogens, including Trypanosoma cruzi, promoting their phagocytosis and lysis by the complement system. Methods We investigated L-ficolin levels in 160 T. cruzi infected patients with chronic Chagas disease and 71 hea...

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Bibliographic Details
Published in:PloS one 2013-04, Vol.8 (4)
Main Authors: Luz, Paola R, Boldt, Angelica BW, Grisbach, Caroline, Kun, Juergen FJ, Velavan, Thirumalaisamy P, Messias-Reason, Iara JT
Format: Article
Language:English
Subjects:
Trypanosoma cruzi
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Summary:Background L-ficolin (encoded by FCN2) binds to acetylated sugar moieties of many pathogens, including Trypanosoma cruzi, promoting their phagocytosis and lysis by the complement system. Methods We investigated L-ficolin levels in 160 T. cruzi infected patients with chronic Chagas disease and 71 healthy individuals, and FCN2 polymorphisms (-986 G>A, -602 G>A, and -4 A>G in the promoter and A258S in exon 8) in 243 patients, being 88 indeterminate (asymptomatic), 96 with cardiac, 23 with digestive and 33 with cardiodigestive manifestations (two were unspecified) and 305 controls (135 for A258S). Results Patients presented lower L-ficolin plasma levels than controls (p
ISSN:1932-6203
DOI:10.1371/journal.pone.0060237