Multivalent alteration of quorum sensing in Staphylococcus aureus

Virulence in Staphylococcus aureus is strongly and positively correlated with local cell density. Here we present an effective approach to modulate this group behaviour using multivalent peptide-polymer conjugates. Our results show that by attaching multiple AIP-4' units to macromolecular scaff...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-06, Vol.49 (45), p.5177-5179
Main Authors: Melamed Yerushalmi, Sarit, Buck, Maren E, Lynn, David M, Lemcoff, N Gabriel, Meijler, Michael M
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Humans
Peptides - chemistry
Peptides - pharmacology
Polymers - chemistry
Polymers - pharmacology
Quorum Sensing - drug effects
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - physiology
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Summary:Virulence in Staphylococcus aureus is strongly and positively correlated with local cell density. Here we present an effective approach to modulate this group behaviour using multivalent peptide-polymer conjugates. Our results show that by attaching multiple AIP-4' units to macromolecular scaffolds, the agr QS response in S. aureus was affected strongly, while displaying a clear multivalency effect.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc41645c