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Multivalent alteration of quorum sensing in Staphylococcus aureus
Virulence in Staphylococcus aureus is strongly and positively correlated with local cell density. Here we present an effective approach to modulate this group behaviour using multivalent peptide-polymer conjugates. Our results show that by attaching multiple AIP-4' units to macromolecular scaff...
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| Published in: | Chemical communications (Cambridge, England) England), 2013-06, Vol.49 (45), p.5177-5179 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c320t-eab618e7cad09c28f2c16ea0fe13a2ae204be9b150df4abe2b333dfc496e1a553 |
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| cites | cdi_FETCH-LOGICAL-c320t-eab618e7cad09c28f2c16ea0fe13a2ae204be9b150df4abe2b333dfc496e1a553 |
| container_end_page | 5179 |
| container_issue | 45 |
| container_start_page | 5177 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 49 |
| creator | Melamed Yerushalmi, Sarit Buck, Maren E Lynn, David M Lemcoff, N Gabriel Meijler, Michael M |
| description | Virulence in Staphylococcus aureus is strongly and positively correlated with local cell density. Here we present an effective approach to modulate this group behaviour using multivalent peptide-polymer conjugates. Our results show that by attaching multiple AIP-4' units to macromolecular scaffolds, the agr QS response in S. aureus was affected strongly, while displaying a clear multivalency effect. |
| doi_str_mv | 10.1039/c3cc41645c |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2013-06, Vol.49 (45), p.5177-5179 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1399917724 |
| source | Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list) |
| subjects | Amino Acid Sequence Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Humans Peptides - chemistry Peptides - pharmacology Polymers - chemistry Polymers - pharmacology Quorum Sensing - drug effects Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - physiology |
| title | Multivalent alteration of quorum sensing in Staphylococcus aureus |
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