Loading…
Association between LEPR and MC4R genes polymorphisms and composition of milk from sows of dam line
The polymorphisms of LEPR and MC4R genes are involved in appetite control mechanisms and indirectly associated with level of fat content in pig carcasses. Therefore, the aim of our study was to determine if both polymorphisms have an effect on components of colostrum and milk of sows. In our study w...
Saved in:
| Published in: | Molecular biology reports 2013-07, Vol.40 (7), p.4339-4347 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c405t-c062a40f012bd0e4370632c0ea64bd8accf82829654fb1d26e429dd347106af23 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c405t-c062a40f012bd0e4370632c0ea64bd8accf82829654fb1d26e429dd347106af23 |
| container_end_page | 4347 |
| container_issue | 7 |
| container_start_page | 4339 |
| container_title | Molecular biology reports |
| container_volume | 40 |
| creator | Szyndler-Nędza, M. Tyra, M. Ropka-Molik, K. Piórkowska, K. Mucha, A. Różycki, M. Koska, M. Szulc, K. |
| description | The polymorphisms of
LEPR
and
MC4R
genes are involved in appetite control mechanisms and indirectly associated with level of fat content in pig carcasses. Therefore, the aim of our study was to determine if both polymorphisms have an effect on components of colostrum and milk of sows. In our study we used gilts of two Polish breeds: Polish Landrace and Polish Large White, which belong to dam-line in Polish breeding. Colostrum and milk of sows were collected in 7, 14 and 21 day of lactation to assay solids, total protein, fat and lactose. The obtained results showed, that the observed mutation (G/A 1426
MC4R
) had a significant effect mainly on the fat and solids content of colostrum. Animals with the
MC4R
AA
genotype had 2.13 and 1.91 % (
P
≤ 0.01) lower fat content of colostrum compared to sows with the
MC4R
GG
genotype and heterozygous
MC4R
AG
. The presence of the
MC4R
A
allele in the animals’ genotype contributed to a decrease in fat and solids content of colostrum. The
LEPR
/HpaII mutation was found to have a considerable effect on the level of most colostrum components (fat, protein and solids) in both pig breeds. Significant decrease in the value of the colostrum components (except lactose) was observed only for animals with the allele
LEPR
B
. The results obtained suggest that these genes might be used in selection of dam-line pigs as genetic markers of milk quality. |
| doi_str_mv | 10.1007/s11033-013-2524-4 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1399917746</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2998932641</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-c062a40f012bd0e4370632c0ea64bd8accf82829654fb1d26e429dd347106af23</originalsourceid><addsrcrecordid>eNqNkV1rFDEUhoModlv9Ad5IwBtvRs9JMsnMZVmqFrZYSr0OmUymTp1MxpxdSv99s90qIgheBXKe983Hw9gbhA8IYD4SIkhZAcpK1EJV6hlbYW1kpVrTPGcrkICVamo8YsdEtwCg0NQv2ZGQWuuSXTF_SpT86LZjmnkXtnchzHxzdnnF3dzzi7W64jdhDsSXNN3HlJfvI0V6HPoUl0TjYzINPI7TDz7kFDmlO9rv9C7yaZzDK_ZicBOF10_rCfv26ex6_aXafP18vj7dVF5Bva08aOEUDICi6yEoaUBL4SE4rbq-cd4PjWhEq2s1dNgLHZRo-14qg6DdIOQJe3_oXXL6uQu0tXEkH6bJzSHtyKJs2xaNUfo_UFOuocovFfTdX-ht2uW5PKRQusWmaYwsFB4onxNRDoNd8hhdvrcIdi_LHmTZIsvuZVlVMm-fmnddDP3vxC87BRAHgMpovgn5j6P_2foALXidAw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1369188873</pqid></control><display><type>article</type><title>Association between LEPR and MC4R genes polymorphisms and composition of milk from sows of dam line</title><source>Springer Nature</source><creator>Szyndler-Nędza, M. ; Tyra, M. ; Ropka-Molik, K. ; Piórkowska, K. ; Mucha, A. ; Różycki, M. ; Koska, M. ; Szulc, K.</creator><creatorcontrib>Szyndler-Nędza, M. ; Tyra, M. ; Ropka-Molik, K. ; Piórkowska, K. ; Mucha, A. ; Różycki, M. ; Koska, M. ; Szulc, K.</creatorcontrib><description>The polymorphisms of
LEPR
and
MC4R
genes are involved in appetite control mechanisms and indirectly associated with level of fat content in pig carcasses. Therefore, the aim of our study was to determine if both polymorphisms have an effect on components of colostrum and milk of sows. In our study we used gilts of two Polish breeds: Polish Landrace and Polish Large White, which belong to dam-line in Polish breeding. Colostrum and milk of sows were collected in 7, 14 and 21 day of lactation to assay solids, total protein, fat and lactose. The obtained results showed, that the observed mutation (G/A 1426
MC4R
) had a significant effect mainly on the fat and solids content of colostrum. Animals with the
MC4R
AA
genotype had 2.13 and 1.91 % (
P
≤ 0.01) lower fat content of colostrum compared to sows with the
MC4R
GG
genotype and heterozygous
MC4R
AG
. The presence of the
MC4R
A
allele in the animals’ genotype contributed to a decrease in fat and solids content of colostrum. The
LEPR
/HpaII mutation was found to have a considerable effect on the level of most colostrum components (fat, protein and solids) in both pig breeds. Significant decrease in the value of the colostrum components (except lactose) was observed only for animals with the allele
LEPR
B
. The results obtained suggest that these genes might be used in selection of dam-line pigs as genetic markers of milk quality.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-013-2524-4</identifier><identifier>PMID: 23666103</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Alleles ; Animal Anatomy ; Animal Biochemistry ; Animals ; Biomedical and Life Sciences ; Breeding ; Colostrum - chemistry ; Gene Frequency ; Genes ; Genetic Association Studies ; Genotype ; Histology ; Hogs ; Lactation - genetics ; Life Sciences ; Milk ; Milk - chemistry ; Milk - standards ; Morphology ; Mutation ; Polymorphism ; Polymorphism, Genetic ; Receptor, Melanocortin, Type 4 - genetics ; Receptors, Leptin - genetics ; Swine</subject><ispartof>Molecular biology reports, 2013-07, Vol.40 (7), p.4339-4347</ispartof><rights>Springer Science+Business Media Dordrecht 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-c062a40f012bd0e4370632c0ea64bd8accf82829654fb1d26e429dd347106af23</citedby><cites>FETCH-LOGICAL-c405t-c062a40f012bd0e4370632c0ea64bd8accf82829654fb1d26e429dd347106af23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23666103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szyndler-Nędza, M.</creatorcontrib><creatorcontrib>Tyra, M.</creatorcontrib><creatorcontrib>Ropka-Molik, K.</creatorcontrib><creatorcontrib>Piórkowska, K.</creatorcontrib><creatorcontrib>Mucha, A.</creatorcontrib><creatorcontrib>Różycki, M.</creatorcontrib><creatorcontrib>Koska, M.</creatorcontrib><creatorcontrib>Szulc, K.</creatorcontrib><title>Association between LEPR and MC4R genes polymorphisms and composition of milk from sows of dam line</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>The polymorphisms of
LEPR
and
MC4R
genes are involved in appetite control mechanisms and indirectly associated with level of fat content in pig carcasses. Therefore, the aim of our study was to determine if both polymorphisms have an effect on components of colostrum and milk of sows. In our study we used gilts of two Polish breeds: Polish Landrace and Polish Large White, which belong to dam-line in Polish breeding. Colostrum and milk of sows were collected in 7, 14 and 21 day of lactation to assay solids, total protein, fat and lactose. The obtained results showed, that the observed mutation (G/A 1426
MC4R
) had a significant effect mainly on the fat and solids content of colostrum. Animals with the
MC4R
AA
genotype had 2.13 and 1.91 % (
P
≤ 0.01) lower fat content of colostrum compared to sows with the
MC4R
GG
genotype and heterozygous
MC4R
AG
. The presence of the
MC4R
A
allele in the animals’ genotype contributed to a decrease in fat and solids content of colostrum. The
LEPR
/HpaII mutation was found to have a considerable effect on the level of most colostrum components (fat, protein and solids) in both pig breeds. Significant decrease in the value of the colostrum components (except lactose) was observed only for animals with the allele
LEPR
B
. The results obtained suggest that these genes might be used in selection of dam-line pigs as genetic markers of milk quality.</description><subject>Alleles</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Breeding</subject><subject>Colostrum - chemistry</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic Association Studies</subject><subject>Genotype</subject><subject>Histology</subject><subject>Hogs</subject><subject>Lactation - genetics</subject><subject>Life Sciences</subject><subject>Milk</subject><subject>Milk - chemistry</subject><subject>Milk - standards</subject><subject>Morphology</subject><subject>Mutation</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Receptor, Melanocortin, Type 4 - genetics</subject><subject>Receptors, Leptin - genetics</subject><subject>Swine</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNkV1rFDEUhoModlv9Ad5IwBtvRs9JMsnMZVmqFrZYSr0OmUymTp1MxpxdSv99s90qIgheBXKe983Hw9gbhA8IYD4SIkhZAcpK1EJV6hlbYW1kpVrTPGcrkICVamo8YsdEtwCg0NQv2ZGQWuuSXTF_SpT86LZjmnkXtnchzHxzdnnF3dzzi7W64jdhDsSXNN3HlJfvI0V6HPoUl0TjYzINPI7TDz7kFDmlO9rv9C7yaZzDK_ZicBOF10_rCfv26ex6_aXafP18vj7dVF5Bva08aOEUDICi6yEoaUBL4SE4rbq-cd4PjWhEq2s1dNgLHZRo-14qg6DdIOQJe3_oXXL6uQu0tXEkH6bJzSHtyKJs2xaNUfo_UFOuocovFfTdX-ht2uW5PKRQusWmaYwsFB4onxNRDoNd8hhdvrcIdi_LHmTZIsvuZVlVMm-fmnddDP3vxC87BRAHgMpovgn5j6P_2foALXidAw</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Szyndler-Nędza, M.</creator><creator>Tyra, M.</creator><creator>Ropka-Molik, K.</creator><creator>Piórkowska, K.</creator><creator>Mucha, A.</creator><creator>Różycki, M.</creator><creator>Koska, M.</creator><creator>Szulc, K.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20130701</creationdate><title>Association between LEPR and MC4R genes polymorphisms and composition of milk from sows of dam line</title><author>Szyndler-Nędza, M. ; Tyra, M. ; Ropka-Molik, K. ; Piórkowska, K. ; Mucha, A. ; Różycki, M. ; Koska, M. ; Szulc, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-c062a40f012bd0e4370632c0ea64bd8accf82829654fb1d26e429dd347106af23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alleles</topic><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Breeding</topic><topic>Colostrum - chemistry</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genetic Association Studies</topic><topic>Genotype</topic><topic>Histology</topic><topic>Hogs</topic><topic>Lactation - genetics</topic><topic>Life Sciences</topic><topic>Milk</topic><topic>Milk - chemistry</topic><topic>Milk - standards</topic><topic>Morphology</topic><topic>Mutation</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Receptor, Melanocortin, Type 4 - genetics</topic><topic>Receptors, Leptin - genetics</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szyndler-Nędza, M.</creatorcontrib><creatorcontrib>Tyra, M.</creatorcontrib><creatorcontrib>Ropka-Molik, K.</creatorcontrib><creatorcontrib>Piórkowska, K.</creatorcontrib><creatorcontrib>Mucha, A.</creatorcontrib><creatorcontrib>Różycki, M.</creatorcontrib><creatorcontrib>Koska, M.</creatorcontrib><creatorcontrib>Szulc, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Proquest Health & Medical Complete</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szyndler-Nędza, M.</au><au>Tyra, M.</au><au>Ropka-Molik, K.</au><au>Piórkowska, K.</au><au>Mucha, A.</au><au>Różycki, M.</au><au>Koska, M.</au><au>Szulc, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between LEPR and MC4R genes polymorphisms and composition of milk from sows of dam line</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>40</volume><issue>7</issue><spage>4339</spage><epage>4347</epage><pages>4339-4347</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>The polymorphisms of
LEPR
and
MC4R
genes are involved in appetite control mechanisms and indirectly associated with level of fat content in pig carcasses. Therefore, the aim of our study was to determine if both polymorphisms have an effect on components of colostrum and milk of sows. In our study we used gilts of two Polish breeds: Polish Landrace and Polish Large White, which belong to dam-line in Polish breeding. Colostrum and milk of sows were collected in 7, 14 and 21 day of lactation to assay solids, total protein, fat and lactose. The obtained results showed, that the observed mutation (G/A 1426
MC4R
) had a significant effect mainly on the fat and solids content of colostrum. Animals with the
MC4R
AA
genotype had 2.13 and 1.91 % (
P
≤ 0.01) lower fat content of colostrum compared to sows with the
MC4R
GG
genotype and heterozygous
MC4R
AG
. The presence of the
MC4R
A
allele in the animals’ genotype contributed to a decrease in fat and solids content of colostrum. The
LEPR
/HpaII mutation was found to have a considerable effect on the level of most colostrum components (fat, protein and solids) in both pig breeds. Significant decrease in the value of the colostrum components (except lactose) was observed only for animals with the allele
LEPR
B
. The results obtained suggest that these genes might be used in selection of dam-line pigs as genetic markers of milk quality.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>23666103</pmid><doi>10.1007/s11033-013-2524-4</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-4851 |
| ispartof | Molecular biology reports, 2013-07, Vol.40 (7), p.4339-4347 |
| issn | 0301-4851 1573-4978 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1399917746 |
| source | Springer Nature |
| subjects | Alleles Animal Anatomy Animal Biochemistry Animals Biomedical and Life Sciences Breeding Colostrum - chemistry Gene Frequency Genes Genetic Association Studies Genotype Histology Hogs Lactation - genetics Life Sciences Milk Milk - chemistry Milk - standards Morphology Mutation Polymorphism Polymorphism, Genetic Receptor, Melanocortin, Type 4 - genetics Receptors, Leptin - genetics Swine |
| title | Association between LEPR and MC4R genes polymorphisms and composition of milk from sows of dam line |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T21%3A47%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20LEPR%20and%20MC4R%20genes%20polymorphisms%20and%20composition%20of%20milk%20from%20sows%20of%20dam%20line&rft.jtitle=Molecular%20biology%20reports&rft.au=Szyndler-N%C4%99dza,%20M.&rft.date=2013-07-01&rft.volume=40&rft.issue=7&rft.spage=4339&rft.epage=4347&rft.pages=4339-4347&rft.issn=0301-4851&rft.eissn=1573-4978&rft_id=info:doi/10.1007/s11033-013-2524-4&rft_dat=%3Cproquest_cross%3E2998932641%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c405t-c062a40f012bd0e4370632c0ea64bd8accf82829654fb1d26e429dd347106af23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1369188873&rft_id=info:pmid/23666103&rfr_iscdi=true |