Brain-derived neurotrophic factor expression after acute administration of ethanol

Earlier findings suggest that, in addition to its well-known neurotrophic role, brain-derived neurotrophic factor (BDNF) is also involved in the rewarding and reinforcing effects of drugs of abuse. The purpose of the present study was to examine the effects of acute administration of ethanol (1.25 o...

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Bibliographic Details
Published in:European journal of pharmacology 2012-07, Vol.687 (1-3), p.9-13
Main Authors: Raivio, Noora, Tiraboschi, Ettore, Saarikoski, Sirkku T., Castrén, Eero, Kiianmaa, Kalervo
Format: Article
Language:English
Subjects:
acute effects
Amygdala
Animals
BDNF
Brain-Derived Neurotrophic Factor - genetics
cortex
drugs
Ethanol
Ethanol - administration & dosage
Ethanol - blood
Ethanol - pharmacokinetics
Frontal cortex
gene expression
Gene Expression Regulation - drug effects
Hippocampus
Male
messenger RNA
Nucleus accumbens
Rats
Rats, Wistar
RNA, Messenger - metabolism
Ventral tegmental area
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Summary:Earlier findings suggest that, in addition to its well-known neurotrophic role, brain-derived neurotrophic factor (BDNF) is also involved in the rewarding and reinforcing effects of drugs of abuse. The purpose of the present study was to examine the effects of acute administration of ethanol (1.25 or 2.5g/kg i.p.) on the expression profile of BDNF in the rat brain by determining the BDNF mRNA expression in the frontal cortex, nucleus accumbens, amygdala, hippocampus, and ventral tegmental area. Ethanol decreased BDNF mRNA levels dose-dependently in the hippocampus, and after the higher ethanol dose in the frontal cortex, nucleus accumbens and amygdala, while increasing them in the ventral tegmental area. Furthermore, BDNF mRNA expression was found to be regulated in a temporally different manner in all investigated brain areas. These data suggest that BDNF is involved in the acute effects of ethanol, but separate brain areas may be differentially engaged in the mediation of these effects.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2012.04.021