Telmisartan Ameliorates Neurotrophic Support and Oxidative Stress in the Retina of Streptozotocin-Induced Diabetic Rats

Neurodegeneration is an early event in the diabetic retina which may lead to diabetic retinopathy. One of the potential pathways in damaging retinal neurons is the activation of renin angiotensin system including angiotensin II type 1 receptor (AT1R) in the diabetic retina. The purpose of this study...

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Bibliographic Details
Published in:Neurochemical research 2013-08, Vol.38 (8), p.1572-1579
Main Authors: Ola, M. Shamsul, Ahmed, Mohammed M., Abuohashish, Hatem M., Al-Rejaie, Salim S., Alhomida, Abdullah S.
Format: Article
Language:English
Subjects:
Angiotensin
Angiotensin II Type 1 Receptor Blockers - pharmacology
Animals
Benzimidazoles - pharmacology
Benzoates - pharmacology
Biochemistry
Biomedical and Life Sciences
Biomedicine
Blood Glucose - analysis
Blotting, Western
Brain-Derived Neurotrophic Factor - blood
Cell Biology
Diabetes Mellitus, Experimental - metabolism
Enzyme-Linked Immunosorbent Assay
Glutathione - blood
Glutathione - metabolism
Male
Neurochemistry
Neurology
Neurosciences
Original Paper
Oxidative Stress - drug effects
Rats
Rats, Wistar
Streptozocin
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Summary:Neurodegeneration is an early event in the diabetic retina which may lead to diabetic retinopathy. One of the potential pathways in damaging retinal neurons is the activation of renin angiotensin system including angiotensin II type 1 receptor (AT1R) in the diabetic retina. The purpose of this study was to determine the effect of telmisartan, an AT1R blocker on retinal level of brain derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF) and tyrosine hydroxylase (TH), glutathione (GSH) and caspase activity in the diabetic rats. The dysregulated levels of these factors are known to cause neurodegeneration in diabetic retina. Three weeks streptozotocin induced diabetic rats were orally treated or untreated with telmisartan (10 mg/kg/day). After 4 weeks of treatments, the levels of BDNF and GSH were found to be increased systemically in the sera as well as in the retina of diabetic rats compared to untreated rats as measured by enzyme-linked immunosorbent assay and biochemical techniques ( p  
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-013-1058-4