Effects of single and combined genotypes of MC4R and POU1F1 genes on two production traits in Langshan chicken

The objective of this study was to analyze the effects of single and combined genotypes of MC4R and POU1F1 genes in Chinese well-known indigenous chicken (Langshan chicken) population. Genetic variants within MC4R gene and POU1F1 gene were screened through PCR-SSCP and DNA sequencing methods. A C/T...

Full description

Saved in:
Bibliographic Details
Published in:Molecular biology reports 2013-07, Vol.40 (7), p.4645-4650
Main Authors: Yan, Lin Jun, Fang, Xing Tang, Liu, Yao, Zhang, Chun Lei, Liu, Xuan Xuan, Zhao, Jing, Li, Jing Jing, Chen, Hong
Format: Article
Language:English
Subjects:
Alleles
Animal Anatomy
Animal Biochemistry
Animals
Biomedical and Life Sciences
Body Weight - genetics
Chickens - genetics
Eggs
Female
Gene Frequency
Genes
Genetic Association Studies
Genotype
Genotype & phenotype
Histology
Life Sciences
Morphology
Poultry
Quantitative Trait, Heritable
Receptor, Melanocortin, Type 4 - genetics
Reproduction - genetics
Transcription Factor Pit-1 - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The objective of this study was to analyze the effects of single and combined genotypes of MC4R and POU1F1 genes in Chinese well-known indigenous chicken (Langshan chicken) population. Genetic variants within MC4R gene and POU1F1 gene were screened through PCR-SSCP and DNA sequencing methods. A C/T mutation at nt 944 in MC4R gene (NC_006089.2:g. 944C>T) and a G/A mutation at nt 3109 in POU1F1 gene (NC_006088.2:g. 3109 G>A) were identified. Associations between the mutations of the two genes with two production traits were analyzed. The results showed that, at MC4R locus, individuals with BB and AB genotypes had highly significantly higher body weight at 16 weeks ( p  
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-013-2558-7