Heat Shock Factor 1 Inducers from the Bark of Eucommia ulmoides as Cytoprotective Agents

The barks of Eucommia ulmoides (Eucommiae Cortex, Eucommiaceae) have been used as a traditional medicine in Korea, Japan, and China to treat hypertension, reinforce the muscles and bones, and recover the damaged liver and kidney functions. Among these traditional uses, to establish the recovery effe...

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Bibliographic Details
Published in:Chemistry & biodiversity 2013-07, Vol.10 (7), p.1322-1327
Main Authors: Nam, Joo-Won, Kim, Seo-Young, Yoon, Taesook, Lee, Yoo Jin, Kil, Yun-Seo, Lee, Yun-Sil, Seo, Eun-Kyoung
Format: Article
Language:English
Subjects:
Cell Line
Coniferaldehyde
Cytoprotective activity
DNA-Binding Proteins - metabolism
Eucommia ulmoides
Eucommiaceae - chemistry
Fibroblasts - drug effects
Fibroblasts - metabolism
Glucosides
Heat shock factor
Heat Shock Transcription Factors
HSP27 Heat-Shock Proteins - genetics
HSP27 Heat-Shock Proteins - metabolism
HSP70 Heat-Shock Proteins - genetics
HSP70 Heat-Shock Proteins - metabolism
Humans
Medicine, East Asian Traditional
Plant Bark - chemistry
Promoter Regions, Genetic
Protective Agents - chemistry
Protective Agents - isolation & purification
Protective Agents - pharmacology
Transcription Factors - metabolism
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Summary:The barks of Eucommia ulmoides (Eucommiae Cortex, Eucommiaceae) have been used as a traditional medicine in Korea, Japan, and China to treat hypertension, reinforce the muscles and bones, and recover the damaged liver and kidney functions. Among these traditional uses, to establish the recovery effects on the damaged organs on the basis of phytochemistry, the barks of E. ulmoides have been investigated to afford three known phenolic compounds, coniferaldehyde glucoside (1), bartsioside (2), and feretoside (3), which were found in the family Eucommiaceae for the first time. The compounds 1–3 were evaluated for their inducible activities on the heat shock factor 1 (HSF1), and heat shock proteins (HSPs) 27 and 70, along with four compounds, geniposide (4), geniposidic acid (5), pinoresinol diglucoside (6), and liriodendrin (7), which were previously reported from E. ulmoides. Compounds 1–7 increased expression of HSF1 by a factor of 1.214, 1.144, 1.153, 1.114, 1.159, 1.041, and 1.167 at 3 μM, respectively. Coniferaldehyde glucoside (1) showed the most effective increase of HSF1 and induced successive expressions of HSP27 and HSP70 in a dose‐dependent manner without cellular cytotoxicity, suggesting a possible application as a HSP inducer to act as cytoprotective agent.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201200401