Percentage of Future Liver Remnant Volume Before Portal Vein Embolization Influences the Degree of Liver Regeneration After Hepatectomy

Background Clinical determinants of liver regeneration induced by portal vein embolization (PVE) and hepatectomy remain unclear. The aims of this study were to investigate how liver regeneration occurs after PVE followed by hepatectomy and to determine which factors strongly promote liver regenerati...

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Bibliographic Details
Published in:Journal of gastrointestinal surgery 2013-08, Vol.17 (8), p.1447-1451
Main Authors: Okabe, Hirohisa, Beppu, Toru, Nakagawa, Shigeki, Yoshida, Morikatsu, Hayashi, Hiromitsu, Masuda, Toshiro, Imai, Katsunori, Mima, Kosuke, Kuroki, Hideyuki, Nitta, Hidetoshi, Hashimoto, Daisuke, Chikamoto, Akira, Ishiko, Takatoshi, Watanabe, Masayuki, Yamashita, Yasuyuki, Baba, Hideo
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Embolization
Embolization, Therapeutic
Female
Gastroenterology
Growth factors
Hepatectomy
Humans
Life sciences
Liver - anatomy & histology
Liver - diagnostic imaging
Liver cancer
Liver cirrhosis
Liver Diseases - surgery
Liver Regeneration
Male
Medicine
Medicine & Public Health
Middle Aged
Organ Size
Original Article
Patients
Portal Vein
Radiography
Regression analysis
Surgery
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Summary:Background Clinical determinants of liver regeneration induced by portal vein embolization (PVE) and hepatectomy remain unclear. The aims of this study were to investigate how liver regeneration occurs after PVE followed by hepatectomy and to determine which factors strongly promote liver regeneration. Methods Thirty-six patients who underwent both preoperative PVE and major hepatectomy were enrolled in this study. Percentage of future liver remnant volume before PVE (%FLR-pre) was compared with the remnant liver volume after PVE (%FLR-post-PVE) and on postoperative day 7 after hepatic resection (%FLR-post-HR). Clinical indicators contributing to liver regeneration induced by both PVE and hepatectomy were examined by logistic regression analysis. Results PVE and hepatectomy caused a two-step regeneration. FLR-pre, FLR-post-PVE, and FLR-post-HR were 448, 579, and 761 cm 3 , respectively. The %FLR-pre was significantly associated with liver regeneration induced by both PVE and hepatectomy ( r  = 0.63, p  
ISSN:1091-255X
1873-4626
DOI:10.1007/s11605-013-2237-y