Steric course of N super(5),N super(10)-methylenetetrahydrofolate formation from glycine by the glycine cleavage system in E. coli

The steric course of the conversion of glycine to 5,10-methylenetetrahydrofolate (5,10-CH sub(2)-H sub(4)folate) by the glycine cleavage system in E. coli) has been elucidated. 2-H sub(re) of glycine is the precursor of 11-H sub(re) of 5,10-CH sub(2)-H sub(4)folate, and 2-H sub(si) of glycine is the...

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Bibliographic Details
Published in:Journal of the American Chemical Society 1984-01, Vol.106 (17), p.4907-4910
Main Authors: Aberhart, D J, Russell, D J
Format: Article
Language:English
Subjects:
Escherichia coli
glycine
Online Access:Get full text
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Summary:The steric course of the conversion of glycine to 5,10-methylenetetrahydrofolate (5,10-CH sub(2)-H sub(4)folate) by the glycine cleavage system in E. coli) has been elucidated. 2-H sub(re) of glycine is the precursor of 11-H sub(re) of 5,10-CH sub(2)-H sub(4)folate, and 2-H sub(si) of glycine is the precursor of 11-H sub(si) of 5,10-CH sub(2)-H sub(4)folate. The overall transformation is at least 78% stereospecific (possibly higher).
ISSN:0002-7863