Progression of microalbuminuria in SHR is associated with lower expression of critical components of the apical endocytic machinery in the renal proximal tubule

Cumulative epidemiological evidence indicates that the presence of microalbuminuria predicts a higher frequency of cardiovascular events, peripheral disease, and mortality in essential hypertension. Microalbuminuria may arise from increased glomerular permeability and/or reduced proximal tubular rea...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 2013-07, Vol.305 (2), p.F216-F226
Main Authors: Inoue, Bruna H, Arruda-Junior, Daniel F, Campos, Luciene C G, Barreto, Ana Luiza T, Rodrigues, Mariliza V, Krieger, José Eduardo, Girardi, Adriana C C
Format: Article
Language:English
Subjects:
Albuminuria - metabolism
Albuminuria - pathology
Albuminuria - physiopathology
Animals
Blood Pressure
Disease Progression
Endocytosis
Epidemiology
Gene expression
Hypertension - metabolism
Hypertension - pathology
Hypertension - physiopathology
Kidney Tubules, Proximal - metabolism
Kidney Tubules, Proximal - pathology
Kidney Tubules, Proximal - physiopathology
Kidneys
Low Density Lipoprotein Receptor-Related Protein-2 - metabolism
Male
Permeability
Proteins
Rats
Rats, Inbred SHR
Rats, Wistar
Receptors, Cell Surface - metabolism
Rodents
Transferrin - secretion
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Summary:Cumulative epidemiological evidence indicates that the presence of microalbuminuria predicts a higher frequency of cardiovascular events, peripheral disease, and mortality in essential hypertension. Microalbuminuria may arise from increased glomerular permeability and/or reduced proximal tubular reabsorption of albumin by receptor-mediated endocytosis. This study aimed to evaluate the temporal pattern of urinary protein excretion and to test the hypothesis that progression of microalbuminuria is associated with decreased protein expression of critical components of the endocytic apparatus in the renal proximal tubule of spontaneously hypertensive rats (SHR). We found that urinary albumin excretion increased progressively with blood pressure in SHR from 6 to 21 wk of age. In addition, SDS-PAGE analysis of urinary proteins showed that microalbuminuric SHR virtually excreted proteins of the size of albumin or smaller (
ISSN:1931-857X
1522-1466
DOI:10.1152/ajprenal.00255.2012