Investigation of the relationship between sleep duration, all-cause mortality, and preexisting disease

Abstract Objective To examine the relationship between sleep duration and mortality and to quantify the likely impact of residual confounding due to poor health status on any observed association. Methods The sample included 227,815 Australian adults aged 45 years and older recruited from 2006–2009...

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Bibliographic Details
Published in:Sleep medicine 2013-07, Vol.14 (7), p.591-596
Main Authors: Magee, Christopher A, Holliday, Elizabeth G, Attia, John, Kritharides, Leonard, Banks, Emily
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Comorbidity
Female
Follow-Up Studies
Health Status
Humans
Male
Middle Aged
Mortality
Neurology
New South Wales - epidemiology
Preexisting disease
Proportional Hazards Models
Prospective
Residual confounding
Risk Factors
Self Report
Sleep
Sleep duration
Sleep Medicine
Sleep Wake Disorders - mortality
Surveys and Questionnaires
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Summary:Abstract Objective To examine the relationship between sleep duration and mortality and to quantify the likely impact of residual confounding due to poor health status on any observed association. Methods The sample included 227,815 Australian adults aged 45 years and older recruited from 2006–2009 (the 45 and Up Study). Sleep duration and relevant covariates (e.g., health status, demographic factors) were assessed through a self-report questionnaire. These data were linked with mortality data from the New South Wales Registry of Births, Deaths, and Marriages up to December 2010 (mean follow-up period, 2.8 y). Cox proportional hazards models examined the relationship between sleep duration and all-cause mortality adjusting for relevant sociodemographic covariates (e.g., age, gender, marital status), with further stratification by baseline health status based on physical functioning and preexisting disease. Results The adjusted mortality risk was significantly higher in individuals reporting
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2013.02.002