Evaluation of protective effect of bee pollen against propoxur toxicity in rat

In this study, 28 Wistar female rats (200–250 g) were used and divided into four equal groups. Group 1 was allocated as the control group. Groups 2–4 were administered 100 mg/kg/bw/day bee pollen, 20 mg/kg/bw/day propoxur, and 100 mg/kg/bw/day bee pollen plus 20 mg/kg/bw/day propoxur by gavage for 1...

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Published in:Ecotoxicology and environmental safety 2009-03, Vol.72 (3), p.931-937
Main Authors: Eraslan, Gökhan, Kanbur, Murat, Silici, Sibel, Cem Liman, Bilal, Altınordulu, Şule, Soyer Sarıca, Zeynep
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - pharmacology
Bee pollen
Bees - physiology
Biochemical parameter
Biomarkers - metabolism
Blood Chemical Analysis
Drug Antagonism
Effect
Female
Insecticides - toxicity
Malondialdehyde - metabolism
Oxidative Stress - drug effects
Oxidoreductases - metabolism
Propolis - pharmacology
Propoxur
Propoxur - toxicity
Rats
Rats, Wistar
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Summary:In this study, 28 Wistar female rats (200–250 g) were used and divided into four equal groups. Group 1 was allocated as the control group. Groups 2–4 were administered 100 mg/kg/bw/day bee pollen, 20 mg/kg/bw/day propoxur, and 100 mg/kg/bw/day bee pollen plus 20 mg/kg/bw/day propoxur by gavage for 14 days, respectively. At the end of the 14th day, blood and tissues (the liver, kidney, brain, and heart) were collected from all animals. Oxidative stress markers (MDA, CAT, SOD, GSH-Px) and some other biochemical parameters (total protein, albumin, glucose, cholesterol, triglyceride, BUN, creatinine, uric acid, magnesium, sodium, potassium, chloride, total bilirubin, GGT, LDH, AST, ALT, and ALP) were analyzed. According to the data obtained, propoxur was determined to lead to negative changes in most of the biochemical parameters investigated and the administration of bee pollen was determined to alleviate these effects.
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2008.06.008