Lung Volume Abnormalities and its Correlation to Spirometric and Demographic Variables in Adult Asthma

Background. Presence of airflow obstruction in asthma has been based on a fixed FEV1(forced expiratory volume at 1 second)/FVC (forced vital capacity) ratio abnormality. The accuracy of FEV1/FVC ratio in diagnosing airflow obstruction remains controversial. Lung volume abnormalities have been observ...

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Bibliographic Details
Published in:The Journal of asthma 2013-08, Vol.50 (6), p.600-605
Main Authors: Jain, Vipul V., Abejie, Belayneh, Bashir, Muhammad H., Tyner, Tim, Vempilly, Joseph
Format: Article
Language:English
Subjects:
Adult
Airway Obstruction - diagnosis
Airway Obstruction - physiopathology
asthma
Asthma - diagnosis
Asthma - physiopathology
Continental Population Groups
Female
FEV
Forced Expiratory Volume
FVC ratio
Humans
Male
Middle Aged
residual volume
RV/TLC ratio
Spirometry
Total Lung Capacity
Vital Capacity
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Summary:Background. Presence of airflow obstruction in asthma has been based on a fixed FEV1(forced expiratory volume at 1 second)/FVC (forced vital capacity) ratio abnormality. The accuracy of FEV1/FVC ratio in diagnosing airflow obstruction remains controversial. Lung volume abnormalities have been observed in severe asthma. We utilized simultaneously measured spirometry and lung volume to determine the utility of residual volume (RV)/total lung capacity (TLC) ratio in diagnosing airflow obstruction and to identify predictors of abnormal RV in asthmatic subjects. Methods. Data from physician-diagnosed asthmatics referred for lung function tests were collected retrospectively. Patient demographics and lung function data were analyzed using general linear modeling. Results. Of the 321 subjects, 221 were female (69%). The ethnicity was Caucasian in 157 (49%), Hispanic in 131 (41%), and African-American in 33 (10%). The percentage of subjects with FEV1/FVC ratio
ISSN:0277-0903
1532-4303
DOI:10.3109/02770903.2013.789058