Catalytic Decarboxylative Alkenylation of Enolates

A palladium-catalyzed decarboxylative alkenylation of stabilized enolates has been developed, which gives rise to alkenylated dicarbonyl products from enol carbonates regioselectively with concomitant installation of a quaternary all-carbon center. The broad scope of the reaction has been demonstrat...

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Bibliographic Details
Published in:Organic letters 2013-07, Vol.15 (14), p.3778-3781
Main Authors: Schröder, Sybrin P, Taylor, Nicholas J, Jackson, Paula, Franckevičius, Vilius
Format: Article
Language:English
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Summary:A palladium-catalyzed decarboxylative alkenylation of stabilized enolates has been developed, which gives rise to alkenylated dicarbonyl products from enol carbonates regioselectively with concomitant installation of a quaternary all-carbon center. The broad scope of the reaction has been demonstrated by successfully utilizing a range of enolates and external phenol nucleophiles.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol401729m