Tri-O-tolyl phosphate neurotoxicity: lack of evidence for autoimmunologic involvement

Studies on the involvement of autoimmunity in the pathogenesis of tri-O-tolyl phosphate (TOTP) induced neurotoxicity in chickens were conducted. Immunosuppressive therapy including gamma-radiation and drug treatments was utilized to determine its effects on the neurotoxic syndrome. Whole-body gamma-...

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Bibliographic Details
Published in:Archives of environmental contamination and toxicology 1977, Vol.6 (2-3), p.233-233
Main Authors: Watanabe, P G, Sharma, R P
Format: Article
Language:English
Subjects:
Animals
Antibodies - analysis
Autoimmune Diseases - chemically induced
Chickens
Complement Fixation Tests
Cresols - adverse effects
Gamma Rays
Immunity, Cellular
Immunosuppressive Agents - pharmacology
Liver - immunology
Nerve Tissue - immunology
Nervous System Diseases - blood
Nervous System Diseases - chemically induced
Nervous System Diseases - immunology
Precipitin Tests
Time Factors
Tritolyl Phosphates - adverse effects
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Summary:Studies on the involvement of autoimmunity in the pathogenesis of tri-O-tolyl phosphate (TOTP) induced neurotoxicity in chickens were conducted. Immunosuppressive therapy including gamma-radiation and drug treatments was utilized to determine its effects on the neurotoxic syndrome. Whole-body gamma-irradiation up to 1020 roentgens failed to show any consistent protection from the TOTP induced paralysis. Therapy involving prednisone alone or in combination with 6-mercaptopurine and antilymphocyte serum likewise indicated no protection. Stimulation of humoral and cellular immunity by TOTP was investigated. Complement fixation, precipitation tests, splenic migration inhibition, and skin tests did not indicate stimulation of autoimmunity toward nervous tissue or liver. The present investigation was unable to demonstrate primary involvement of an autoimmune nature in the neurotoxicity produced by TOTP in the chicken.
ISSN:0090-4341