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The effects of total‐body hyperthermia combined with anticancer drugs on immunity in advanced cancer patients
As total‐body hyperthermia (TBHT) therapy may lead to a reduction in the immune response of cancer patients because of the immediate effect of heat on lymphocytes, the authors studied the immunity of advanced cancer patients receiving combined TBHT and anticancer chemotherapy. A decrease was found i...
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| Published in: | Cancer 1983-10, Vol.52 (7), p.1173-1177 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4448-15c038e2f18e568b596be1c3d1a96dc751d01d8ad535c1d641b315f448ce1ea93 |
| container_end_page | 1177 |
| container_issue | 7 |
| container_start_page | 1173 |
| container_title | Cancer |
| container_volume | 52 |
| creator | Koga, Shigemasa Izumi, Akio Maeta, Michiro Shimizu, Norio Osaki, Yukio Kanayama, Hirotomo |
| description | As total‐body hyperthermia (TBHT) therapy may lead to a reduction in the immune response of cancer patients because of the immediate effect of heat on lymphocytes, the authors studied the immunity of advanced cancer patients receiving combined TBHT and anticancer chemotherapy. A decrease was found in their lymphocyte blastogenesis, skin reactions to PPD and PHA, lymphocyte rosette formation, IgG, and C3c component. These parameters returned to their pretreatment levels at 1 week after completion of TBHT therapy. This result indicates that there is no necessity for giving special consideration to a reduction of cell‐mediated immunity in TBHT therapy. |
| doi_str_mv | 10.1002/1097-0142(19831001)52:7<1173::AID-CNCR2820520708>3.0.CO;2-0 |
| format | article |
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A decrease was found in their lymphocyte blastogenesis, skin reactions to PPD and PHA, lymphocyte rosette formation, IgG, and C3c component. These parameters returned to their pretreatment levels at 1 week after completion of TBHT therapy. This result indicates that there is no necessity for giving special consideration to a reduction of cell‐mediated immunity in TBHT therapy.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19831001)52:7<1173::AID-CNCR2820520708>3.0.CO;2-0</identifier><identifier>PMID: 6411322</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Complement System Proteins - analysis ; Cyclophosphamide - administration & dosage ; Doxorubicin - administration & dosage ; Female ; Fever - physiopathology ; Fluorouracil - administration & dosage ; Gastrointestinal Neoplasms - immunology ; Hot Temperature - therapeutic use ; Humans ; Immunity - drug effects ; Immunoglobulins - analysis ; Induced hyperthermia. Cryotherapy ; Lymphocytes - immunology ; Male ; Medical sciences ; Middle Aged ; Mitomycin ; Mitomycins - administration & dosage ; Neoplasms - drug therapy ; Neoplasms - immunology ; Neoplasms - therapy ; Treatment with physical agents ; Treatment. 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A decrease was found in their lymphocyte blastogenesis, skin reactions to PPD and PHA, lymphocyte rosette formation, IgG, and C3c component. These parameters returned to their pretreatment levels at 1 week after completion of TBHT therapy. This result indicates that there is no necessity for giving special consideration to a reduction of cell‐mediated immunity in TBHT therapy.</description><subject>Adult</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Complement System Proteins - analysis</subject><subject>Cyclophosphamide - administration & dosage</subject><subject>Doxorubicin - administration & dosage</subject><subject>Female</subject><subject>Fever - physiopathology</subject><subject>Fluorouracil - administration & dosage</subject><subject>Gastrointestinal Neoplasms - immunology</subject><subject>Hot Temperature - therapeutic use</subject><subject>Humans</subject><subject>Immunity - drug effects</subject><subject>Immunoglobulins - analysis</subject><subject>Induced hyperthermia. Cryotherapy</subject><subject>Lymphocytes - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mitomycin</subject><subject>Mitomycins - administration & dosage</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - therapy</subject><subject>Treatment with physical agents</subject><subject>Treatment. 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Cryotherapy</topic><topic>Lymphocytes - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mitomycin</topic><topic>Mitomycins - administration & dosage</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - therapy</topic><topic>Treatment with physical agents</topic><topic>Treatment. 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A decrease was found in their lymphocyte blastogenesis, skin reactions to PPD and PHA, lymphocyte rosette formation, IgG, and C3c component. These parameters returned to their pretreatment levels at 1 week after completion of TBHT therapy. This result indicates that there is no necessity for giving special consideration to a reduction of cell‐mediated immunity in TBHT therapy.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>6411322</pmid><doi>10.1002/1097-0142(19831001)52:7<1173::AID-CNCR2820520708>3.0.CO;2-0</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-543X |
| ispartof | Cancer, 1983-10, Vol.52 (7), p.1173-1177 |
| issn | 0008-543X 1097-0142 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14088710 |
| source | EZB Free E-Journals |
| subjects | Adult Antineoplastic Agents - therapeutic use Biological and medical sciences Complement System Proteins - analysis Cyclophosphamide - administration & dosage Doxorubicin - administration & dosage Female Fever - physiopathology Fluorouracil - administration & dosage Gastrointestinal Neoplasms - immunology Hot Temperature - therapeutic use Humans Immunity - drug effects Immunoglobulins - analysis Induced hyperthermia. Cryotherapy Lymphocytes - immunology Male Medical sciences Middle Aged Mitomycin Mitomycins - administration & dosage Neoplasms - drug therapy Neoplasms - immunology Neoplasms - therapy Treatment with physical agents Treatment. General aspects Tumors |
| title | The effects of total‐body hyperthermia combined with anticancer drugs on immunity in advanced cancer patients |
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