Monoclonal IgM with anti-muscle tissue activity in a patient with Waldenstroem's macroglobulinaemia: Secretion of identical immunoglobulin by the established lymphoid cell line

The monoclonal IgM Kappa protein from a patient with Waldenstroem's macroglobulinaemia displayed antibody like activity against muscle and alpha -actinin. An Epstein-Barr virus associated lymphoid cell line, spontaneously established from blood lymphocytes, has been continuously secreting an im...

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Bibliographic Details
Published in:Clinical and experimental immunology 1984-01, Vol.58 (3), p.677-684
Main Authors: Micouin, C, Seigneurin, J M, Renversez, J C, Roussel, B, Favre, M
Format: Article
Language:English
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Summary:The monoclonal IgM Kappa protein from a patient with Waldenstroem's macroglobulinaemia displayed antibody like activity against muscle and alpha -actinin. An Epstein-Barr virus associated lymphoid cell line, spontaneously established from blood lymphocytes, has been continuously secreting an immunoglobulin of the same isotype, isoelectric focusing spectrotype and reactivity; the cell line is probably leukaemic in origin since all cells display the translocation t(1 ; 19) and are aneuploid. The authors suggest these two monoclonal immunoglobulins have a common malignant origin.
ISSN:0009-9104