A nested case-control study to evaluate the association between fetal growth restriction and vitamin B12 deficiency

• Published in: Australian & New Zealand journal of obstetrics & gynaecology 2013-08, Vol.53 (4), p.399-402
• Main Authors: Abraham, Anuja, Mathews, Jiji E., Sebastian, Ajit, Chacko, Kuruvilla P., Sam, Dibu
• Format: Article
• Language: English
• Subjects: Adult; Case-Control Studies; Female; Fetal Development - drug effects; fetal growth restriction; Fetal Growth Retardation - etiology; Humans; Infant, Low Birth Weight; nested case control; Nutritional Status; poor nutrition; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Third - blood; Social Class; socioeconomic status; Vitamin B 12 Deficiency - complications; vitamin B12
• ISSN: 0004-8666; 1479-828X
• DOI: 10.1111/ajo.12057

Objectives To study the association between maternal vitamin B12 levels and fetal growth restriction. Methods In this nested case–control study, a cohort of low‐risk women attending the antenatal clinic had their blood samples taken and stored at 28–31 weeks gestation. They were followed until delivery. Fifty‐eight women delivering babies less than 2500 g were taken as cases and an equal number of controls delivering babies more than 2500 g were taken from the same cohort. Their B12 levels were assayed and studied for statistical significance. Results The baseline characteristics of both groups were similar. The number of women with serum B12 levels less than 200 pg/mL were similar in both groups: 33% versus 29% (P = 0.84). Type of kitchen fuel used was taken as a surrogate marker for socioeconomic status. More women in the cases used non‐LPG (liquid petroleum gas) kitchen fuels such as kerosene and wood than in controls, 35% versus 19% (P = 0.06). Conclusions No association between maternal vitamin B12 levels and fetal growth restriction was found in this study. Low birth weight babies were more common in women of low socioeconomic status.