Evaluation of contributing factors of post transplant erythrocytosis in renal transplant patients

To evaluate the prevalence and contributing factors causing post transplant erythrocytosis in renal transplant patients. This retrospective study was conducted on live related renal transplant patients at SIUT. The records of all transplant recipients transplanted between April 2008 and December 200...

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Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2012-12, Vol.62 (12), p.1326-1329
Main Authors: Ahmed, Saima, Ahmed, Ejaz, Naqvi, Rubina, Qureshi, Sehar
Format: Article
Language:English
Subjects:
Adult
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Care and treatment
Creatinine - blood
Diagnosis
Enalapril - therapeutic use
Female
Hematocrit
Humans
Kidney Transplantation
Kidneys
Male
Pakistan - epidemiology
Polycythemia
Polycythemia - drug therapy
Polycythemia - epidemiology
Polycythemia - etiology
Postoperative care
Prevalence
Retrospective Studies
Risk Factors
Transplantation
Treatment Outcome
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Summary:To evaluate the prevalence and contributing factors causing post transplant erythrocytosis in renal transplant patients. This retrospective study was conducted on live related renal transplant patients at SIUT. The records of all transplant recipients transplanted between April 2008 and December 2008 and who had at least 24 months follow up were studied. Patients in whom haematocrit exceeded 51% and those who received treatment for it were classified into post transplant erythrocytosis group. Out of 200 renal transplant patients who had functioning graft at the time of analysis, 40 (20%) developed post transplant erythrocytosis (HCT > or = 51%) after a mean interval of 9.5 +/- 2.5 months. Patients with erythrocytosis were mostly males (95% in PTE group vs 73.75% in non PTE group), had a shorter period on dialysis before undergoing renal transplantation (9.28 months in PTE group vs 14.56 months in non PTE group) and had relatively better graft function at the onset of erythrocytosis as judged by serum creatinine (S. Creatinine of 1.06 +/- 0.29 mg/dl in PTE group vs 1.37 +/- 0.51 mg/dl in non PTE group). No thrombotic complications were observed. All patients with erythrocytosis were treated with enalapril (ACE inhibitors) and 28 out of 40 required phlebotomy in addition to ACE inhibitors. The mean HCT at the time of last follow up in treated patients was 48.61 +/- 1.85%. Post transplant erythrocytosis generally occurs in male patients with good graft function, thrombotic complications are of rare occurrence and response to ACE inhibitors is good.
ISSN:0030-9982