Co-purification of a transforming growth factor (TGF) with bone resorbing activity in the Walker rat carcinosarcoma: A mechanism for the humoral hypercalcemia of malignancy (HHM)

Hypercalcemia is a frequent complication of malignancy. Previous studies with a rat Leydig cell tumor showed that HHM was due to a bone resorbing TGF which inhibited the binding of epidermal growth factor (EGF) to its receptors and which stimulated colony formation of anchorage-dependent non-transfo...

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Bibliographic Details
Published in:Calcified tissue international 1983-01, Vol.35 (4-5)
Main Authors: D'Souza, S M, Ibbotson, K J, Smith, D D, Mundy, G R
Format: Article
Language:English
Online Access:Get full text
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Summary:Hypercalcemia is a frequent complication of malignancy. Previous studies with a rat Leydig cell tumor showed that HHM was due to a bone resorbing TGF which inhibited the binding of epidermal growth factor (EGF) to its receptors and which stimulated colony formation of anchorage-dependent non-transformed fibroblasts in soft agar (the key characteristic of TGFs). The authors show here that a different class of TGF (which does not inhibit binding of EGF) is responsible for HHM in the Walker rat 256 carcinosarcoma breast tumor. In conclusion the results suggest that HHM in the Walker rat carcinosarcoma is due to a bone resorbing TGF which is distinct from any previously described bone resorbing factor.
ISSN:0171-967X