Early New Diffusion-Weighted Imaging Lesions Appear More Often in Stroke Patients With a Multiple Territory Lesion Pattern

• Published in: Stroke (1970) 2013-08, Vol.44 (8), p.2200-2204
• Main Authors: Braemswig, Tim Bastian, Usnich, Tatiana, Albach, Fredrik N, Brunecker, Peter, Grittner, Ulrike, Scheitz, Jan F, Fiebach, Jochen B, Nolte, Christian H
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Brain - pathology; Brain Ischemia - pathology; Cerebral Infarction - classification; Cerebral Infarction - pathology; Diffusion Magnetic Resonance Imaging - instrumentation; Diffusion Magnetic Resonance Imaging - methods; Female; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Male; Medical sciences; Middle Aged; Nervous system (semeiology, syndromes); Neurology; Risk Factors; Severity of Illness Index; Stroke - pathology; Time Factors; Vascular diseases and vascular malformations of the nervous system
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/STROKEAHA.111.000810

BACKGROUND AND PURPOSE—New diffusion-weighted imaging (DWI) lesions are common in patients with acute ischemic stroke. They are associated with an initial nonsingle lesion pattern. Previous studies have not analyzed this association in detail. We differentiated nonsingle lesions in 1 vascular supply territory only (scattered lesion pattern) from nonsingle lesions in ≥2 vascular supply territory (multiple territory lesion -pattern). METHODS—Patients with an acute ischemic stroke underwent 3 MRI (3T) examinationson admission, on the following day, and 4 to 7 days after symptom onset. First, DWI lesions were delineated manually by raters blinded to clinical details. Second, DWI images were coregistered and analyzed visually for new hyperintensities. The initial lesion pattern was categorized as single, scattered, or multiple territory. RESULTS—Of 340 patients enrolled, 43% had a single lesion pattern, 40% had a scattered lesion pattern, and 17% had a multiple territory lesion pattern. In multivariable analysis, the categorical variable lesion pattern was independently associated with new DWI lesions (odds ratiomultiple territory lesion pattern, 3.64 [95% confidence interval, 1.75–7.58]; odds ratioscattered lesion pattern, 1.96 [95% confidence interval, 1.09–3.56]). Patients with multiple territory lesion pattern had significantly more often diabetes mellitus, and their new lesions were more often located remotely from the initial area of hypoperfusion compared with patients with scattered lesion pattern. CONCLUSION—Lesion pattern on initial image is an independent risk factor for new DWI lesions. The risk for new DWI lesions is highest in patients with multiple territory lesion pattern.