Thyroid disease associated with cowden syndrome: A meta-analysis

Background We investigated the pathology and surgical management of thyroid disease in patients with Cowden syndrome (CS). Methods A query of the PubMed database between 2001 and January 2010 was performed using the terms “cowden syndrome OR cowden's syndrome OR cowden disease OR cowden's...

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Bibliographic Details
Published in:Head & neck 2013-08, Vol.35 (8), p.1189-1194
Main Authors: Hall, Joseph E., Abdollahian, Davood J., Sinard, Robert J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Child
Child, Preschool
Cowden Disease
Cowden Syndrome
Female
Hamartoma Syndrome, Multiple - complications
Humans
Infant
Infant, Newborn
Male
Middle Aged
pathology
surgical management
thyroid
Thyroid Diseases - complications
Thyroid Diseases - pathology
Thyroid Diseases - surgery
Thyroidectomy
Young Adult
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Summary:Background We investigated the pathology and surgical management of thyroid disease in patients with Cowden syndrome (CS). Methods A query of the PubMed database between 2001 and January 2010 was performed using the terms “cowden syndrome OR cowden's syndrome OR cowden disease OR cowden's disease.” Original articles, reviews, case reports, and case series were included. Articles were excluded if they were not written in English, did not present case/cases of CS, or did not include patient information to qualify for a diagnosis of CS. Ninety‐five articles met the inclusion and exclusion criteria. A total of 181 cases were analyzed. Results Of the 181 patients, 99 female (54.7%) and 77 male patients (42.5%) had sex reported. The age at presentation ranged from 3 days to 78 years. Ninety‐six patients (96/181, 53.0%) were reported to have thyroid disease. Surgical management of thyroid disease was performed in 80.2% (77/96) of patients with thyroid disease, with total thyroidectomy being the most common operation reported (23/77, 29.9%). Thyroid pathology reported with CS patients included goiter (39/96, 40.6%), adenoma (24/96, 25%), unknown/unspecified pathology (8/96, 8.3%), follicular carcinoma (7/96, 7.3%), thyroiditis (7/96, 7.3%), papillary carcinoma (6/96, 6.3%), cancer (unknown type) (3/96, 3.1%), medullary carcinoma (1/96, 1%), and hyperthyroidism (1/96, 1%). Conclusion Careful monitoring of thyroid disease in CS patients is imperative. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.22971