Shared epitope and radiologic progression are less prominent in elderly onset RA than young onset RA

The aim of this study was to determine the influence of HLA-DRB1 and HLA-DQB1 genes on the disease susceptibility and the disease severity in elderly onset rheumatoid arthritis (EORA) compared with young onset rheumatoid arthritis (YORA) in Korean patients. Genetic analysis of HLA-DRB1 and HLA-DQB1...

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Bibliographic Details
Published in:Rheumatology international 2013-08, Vol.33 (8), p.2135-2140
Main Authors: Kim, Eun-Ji, Lee, Jennifer, Ryu, Yang-Sun, Kim, Ji-Min, Jeong, Yong-Geun, Kwok, Seung-Ki, Ju, Ji-Hyeon, Park, Kyung-Su, Park, Sung-Hwan, Choi, Hee-Baeg, Kim, Tai-Gyu, Kim, Ho-Youn
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Aged
Alleles
Arthritis, Rheumatoid - diagnostic imaging
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - immunology
Disease Progression
Epitopes - genetics
Epitopes - immunology
Female
Genetic Predisposition to Disease
Hand Joints - diagnostic imaging
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Radiography
Retrospective Studies
Rheumatology
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Summary:The aim of this study was to determine the influence of HLA-DRB1 and HLA-DQB1 genes on the disease susceptibility and the disease severity in elderly onset rheumatoid arthritis (EORA) compared with young onset rheumatoid arthritis (YORA) in Korean patients. Genetic analysis of HLA-DRB1 and HLA-DQB1 alleles was performed in three groups. Group 1 included 63 patients who were diagnosed with (rheumatoid arthritis) RA after the age of 60 (EORA). Group 2 consisted of 109 patients who were diagnosed with RA before the age of 60 (YORA). Group 3 involved 133 normal controls. The shared-epitope-coding alleles included the members of the HLA-DRB1*04 allele group (*0401, *0404, *0405, *0408, *0410), HLA-DRB1*01 allele group (*0101,*0102), HLA-DRB1*1001, and HLA-DRB1*1402. The disease severity was assessed by the modified total sharp score (mTSS). The shared-epitope-coding alleles were more frequently observed in the RA patients than in the normal controls. The shared-epitope-coding alleles were less frequently found in EORA group than YORA group (31/63 (49.2 %) in group 1, 72/109 (66.1 %) in group 2, 45/133 (33.8 %) group 3, p  = 0.02). Although the mTSS of the group 1 was higher than group 2 at symptom onset, the overall mean mTSS of the group 1 was lower than that of group 2 (26.8 vs. 57.5, p  
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-013-2670-y