Hypolipidemic effects of starch and γ-oryzanol from wx/ae double-mutant rice on BALB/c.KOR-Apoe(shl) mice

waxy/amylose-extender (wx/ae) double-mutant japonica rice (Oryza sativa L.) produces resistant starch (RS) and a large amount of γ-oryzanol. Our previous study has shown the hypolipidemic effect of wx/ae brown rice on mice. To identify the functional constituents of the hypolipidemic activity in wx/...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2013, Vol.77 (7), p.1435-1440
Main Authors: Nakaya, Makoto, Shojo, Aiko, Hirai, Hiroaki, Matsumoto, Kenji, Kitamura, Shinichi
Format: Article
Language:English
Subjects:
Animals
Apolipoproteins E - deficiency
Apolipoproteins E - genetics
Body Weight - drug effects
Cecum - drug effects
Cecum - metabolism
Diet, High-Fat - adverse effects
Dietary Carbohydrates - adverse effects
Drug Interactions
Eating - drug effects
Fatty Liver - prevention & control
Feces
Food, Genetically Modified
Gene Expression Regulation - drug effects
Hypolipidemic Agents - pharmacology
Liver - drug effects
Liver - metabolism
Male
Mice
Mice, Inbred BALB C
Mutation
Non-alcoholic Fatty Liver Disease
Oryza - chemistry
Oryza - genetics
Phenylpropionates - pharmacology
Starch - pharmacology
Sucrose - adverse effects
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Summary:waxy/amylose-extender (wx/ae) double-mutant japonica rice (Oryza sativa L.) produces resistant starch (RS) and a large amount of γ-oryzanol. Our previous study has shown the hypolipidemic effect of wx/ae brown rice on mice. To identify the functional constituents of the hypolipidemic activity in wx/ae rice, we prepared pure wx/ae starch and γ-oryzanol from wx/ae rice and investigated their effect on the lipid metabolism in BALB/c.KOR/Stm Slc-Apoe(shl) mice. The mice were fed for 3 weeks a diet containing non-mutant rice starch, non-mutant rice starch plus γ-oryzanol, wx/ae starch, or wx/ae starch plus γ-oryzanol. γ-Oryzanol by itself had no effect on the lipid metabolism, and wx/ae starch prevented an accumulation of triacylglycerol (TAG) in the liver. Interestingly, the combination of wx/ae starch plus γ-oryzanol not only prevented a TAG accumulation in the liver, but also partially suppressed the rise in plasma TAG concentration, indicating that wx/ae starch and γ-oryzanol could have a synergistic effect on the lipid metabolism.
ISSN:1347-6947
DOI:10.1271/bbb.130087