Sasa quelpaertensis and p-Coumaric Acid Attenuate Oleic Acid-Induced Lipid Accumulation in HepG2 Cells

In this study, we examined the effects of Jeju dwarf bamboo (Sasa quelpaertensis Nakai) extract (JBE) and p-coumaric acid (CA) on oleic acid (OA)-induced lipid accumulation in HepG2 cells. JBE and CA increased the phosphorylation of AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase (AC...

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Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2013, Vol.77 (7), p.1595-1598
Main Authors: KIM, Jeong-Hwan, KANG, Seong-Il, SHIN, Hye-Sun, YOON, Seon-A, KANG, Seung-Woo, KO, Hee-Chul, KIM, Se-Jae
Format: Article
Language:English
Subjects:
AMP-activated protein kinase
AMP-Activated Protein Kinases - metabolism
Coumaric Acids - pharmacology
Enzyme Activation - drug effects
Hep G2 Cells
HepG2 cells
Humans
Lipid Metabolism - drug effects
Oleic Acid - pharmacology
p-coumaric acid
Plant Extracts - pharmacology
Propionates
Sasa
Sasa - chemistry
Sasa quelpaertensis Nakai
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Summary:In this study, we examined the effects of Jeju dwarf bamboo (Sasa quelpaertensis Nakai) extract (JBE) and p-coumaric acid (CA) on oleic acid (OA)-induced lipid accumulation in HepG2 cells. JBE and CA increased the phosphorylation of AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase (ACC) and the expression of carnitine palmitoyl transferase 1a (CPT1a) in OA-treated HepG2 cells. Additionally, these compounds decreased sterol regulatory element-binding protein-1c (SREBP-1c), fatty acid synthase (FAS), and OA-induced lipid accumulation, suggesting that JBE and CA modulate lipid metabolism in HepG2 cells via the AMPK activation pathway.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.130167