Two distinct resistance determinants to nucleic acid‐binding compounds in Staphylococcus aureus?

The majority of methicillin‐resistant Staphylococcus aureus isolated in Australia since 1980 carries a determinant encoding resistance to a variety of nucleic acid‐binding (NAB) compounds, including ethidium bromide (EB) acriflavine and propamidine isothionate. In addition, an EB‐resistance determin...

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Bibliographic Details
Published in:FEMS microbiology letters 1985-04, Vol.27 (1), p.61-64
Main Authors: Emslie, K.R., Townsend, D.E., Bolton, S., Grubb, W.B.
Format: Article
Language:English
Subjects:
aminoglycoside
Bacteriology
Biological and medical sciences
ethidium bromide
Fundamental and applied biological sciences. Psychology
Genetics
Microbiology
Propamidine isothionate
resistance plasmids
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Summary:The majority of methicillin‐resistant Staphylococcus aureus isolated in Australia since 1980 carries a determinant encoding resistance to a variety of nucleic acid‐binding (NAB) compounds, including ethidium bromide (EB) acriflavine and propamidine isothionate. In addition, an EB‐resistance determinant is frequently located on conjugative plasmids encoding aminoglycoside resistance. A comparison of these two determinants revealed that the EB‐resistance determinant also encoded resistance to several NAB compounds. However, the NAB‐ and the EB‐resistance determinants differed in both the number of NAB‐compounds to which they expressed resistance, and the level of resistance expressed towards these compounds. Whilst these 2 determinants have several features in common, the results suggest that the NAB‐ and EB‐resistance determinants are not identical.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.1985.tb01639.x