Risk factors of recurrence in small-sized, node negative breast cancer in young women： a retrospective study in Chinese population

• Published in: Science China. Life sciences 2013-04, Vol.56 (4), p.335-340
• Main Authors: Zhang, XiaoSan, Li, PengFei, Ma, WenJie, Di, WenYu, Zhao, Shu, Gao, QingZu, Zhao, YuYing, Yang, MaoPeng, Zhang, QingYuan
• Format: Article
• Language: English
• Subjects: Adult; Asian Continental Ancestry Group; Biomedical and Life Sciences; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Breast Neoplasms - surgery; China; Female; Humans; Kaplan-Meier Estimate; Ki-67 Antigen - metabolism; Life Sciences; Lymphatic Metastasis; Multivariate Analysis; Neoplasm Recurrence, Local - ethnology; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Pregnancy; Prognosis; Proportional Hazards Models; Receptor, ErbB-2 - metabolism; Receptors, Estrogen - metabolism; Receptors, Progesterone - metabolism; Research Paper; Retrospective Studies; Risk Assessment - statistics & numerical data; Risk Factors; Treatment Outcome; Young Adult; 中国人群; 乳腺癌; 危险因素; 复发; 女性; 淋巴结; 肿瘤患者; 阴性
• ISSN: 1674-7305; 1869-1889
• DOI: 10.1007/s11427-013-4435-y

We aimed to investigate risk factors of local and distant recurrence in small-sized, node negative breast cancer in women 〈35 years in a Chinese cohort. Between January 1994 and January 2007, 107 patients with pathologically confirmed small-sized （E1 cm）, node negative breast cancer who did not receive neoadjuvant or adjuvant chemotherapy were included. The 5-year recurrence-free survival （RFS） was estimated according to different prognostic variables. With a median time of 60 months （range, 8-60 months） follow-up, local and distant recurrence were observed in 25 cases （23.4%）. By univariate analysis, HER-2 positivity, triple negative （TN）, and high Ki-67 index （~14%） were risk factors of a lower RFS （hazard ratio （HR） 6.680, 95% confidence interval （CI） 2.350-18.985, P〈0.0001 for HER-2 positive; HR 4.769, 95%CI 1.559-14.591, P=0.006 for TN; HR 6.030, 95%CI 2.659-13.674, P〈0.0001 for high Ki-67 index）. Patients with grade 3 tumors had a lower RFS （HR 2.922, 95%CI 1.096-7.791, P=0.032） compared with those with grade 1 or grade 2 tumors. By multivariate analysis, HER-2 positivity （HR 10.204, 95%CI 3.391-30.704, P〈0.0001）, TN （HR 10.521, 95% CI 3.152-35.113, P〈0.0001） and high Ki-67 index （HR 10.820, 95%CI 4.338-27.002, P〈0.0001） remained risk factors of RFS. In this cohort, HER-2 positivity, triple neg- ative and high Ki-67 index were independent risk factors of RFS in young patients with Tla,bN0 breast cancer. Subsequent pregnancy did not affect RFS.