Circulating CLA+ T lymphocytes as peripheral cell biomarkers in T-cell-mediated skin diseases

T lymphocytes expressing the CLA antigen constitute a subset of effector memory lymphocytes that are functionally involved in T‐cell‐mediated cutaneous diseases. Skin‐seeking lymphocytes recirculate between inflamed skin and blood during cutaneous inflammation. Many studies in different T‐cell‐media...

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Bibliographic Details
Published in:Experimental dermatology 2013-07, Vol.22 (7), p.439-442
Main Authors: Ferran, Marta, Romeu, Ester R., Rincón, Catalina, Sagristà, Marc, Giménez Arnau, Ana M., Celada, Antonio, Pujol, Ramon M., Holló, Péter, Jókai, Hajnalka, Santamaria-BabÍ, Luis F.
Format: Article
Language:English
Subjects:
Animals
Antigens, Differentiation, T-Lymphocyte - metabolism
associated antigen
biomarker
Biomarkers - metabolism
cutaneous lymphocyte
Humans
Immunologic Memory
Inflammation
Membrane Glycoproteins - metabolism
Mice
Phenotype
Psoriasis - immunology
Skin Diseases - immunology
Skin Neoplasms - immunology
skin-homing
T lymphocyte
T-Lymphocytes - cytology
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Summary:T lymphocytes expressing the CLA antigen constitute a subset of effector memory lymphocytes that are functionally involved in T‐cell‐mediated cutaneous diseases. Skin‐seeking lymphocytes recirculate between inflamed skin and blood during cutaneous inflammation. Many studies in different T‐cell‐mediated inflammatory cutaneous diseases have clearly related their pathologic mechanisms to CLA+ T cells. Based on common features of these cells in different cutaneous disorders mediated by T cells, we propose that circulating CLA+T cells could constitute very useful peripheral cellular biomarkers for T‐cell‐mediated skin diseases.
ISSN:0906-6705
1600-0625
DOI:10.1111/exd.12154